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| Progress on Biosynthesis of Antibacterial compounds from Bacillus subtilis |
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Abstract The endospore-forming rhizobacterium Bacillus subtilis is able to produce a variety of polypeptides and peptide-derived antimicrobial compounds that are synthesized ribosomally or generated non-ribosomally. Non-ribosomal peptides contain lipopeptides and oligo-peptides, the molecular weight of which is less than 3,000 Da and that are catalyzed by employing multienzyme complexes (nonribosomal peptide synthetases, NRPSs) after growth has ceased, while the molecular weight of ribosomal peptides is much more than 30 kDa and they are synthesized during active growth. Both biosynthesis and regulation of NRPSs and ribosomal peptides are controlled by a series of gene, called gene clusters. Biosynthesis and gene regulation of non-ribosomal and ribosomal peptides were reviewed in this paper.
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Received: 18 June 2010
Published: 19 October 2010
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