The Action of Protease Activating factor Apaf-2/CytC on Apoptosis

China Biotechnology

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The Action of Protease Activating factor Apaf-2/CytC on Apoptosis

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Abstract This article has described the action of Apaf-2/CytC on apoptosis. It has mainly set forth the discovery of apoptosis-correlation element Apaf-2/CytC, the action of Apaf-2,Apaf-1 and Apaf-3 on apoptosis and their relations, the manner of CytC mediating the apoptosis. It has also discussed the mechanism of CytC leakage in the mitochondria, and set forth the MPTP hypothesis, specific tunnel hypothesis and mitochondria swelling. It has analyzed the signal transferring pathway of Apaf-2/CytC-mediated apoptosis, such as CytC pathway, Fas/FasL pathway, protein kinase pathway, apoptosis inducing factor pathway and their cross talking. Finally, it has analyzed the meaning of studying the molecular mechanism of CytC-mediated apoptosis, and put forward the problem existed in the research of molecular mechanism of apoptosis.

Key words： apoptotic pathway mitochondria leakage Apaf-2/cytochrome c

Received: 10 February 2006 Published: 25 March 2006

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Cite this article:

. The Action of Protease Activating factor Apaf-2/CytC on Apoptosis. China Biotechnology, 2006, 26(03): 89-92.

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https://manu60.magtech.com.cn/biotech/ OR https://manu60.magtech.com.cn/biotech/Y2006/V26/I03/89

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