Research Progress on Hepatitis C Virus Multi-epitope DNA Vaccine

China Biotechnology

2007, Vol. 27

Issue (1): 119-125 DOI:

Research Progress on Hepatitis C Virus Multi-epitope DNA Vaccine

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Abstract Hepatitis C virus (HCV) is the major etiology of non-A, non-B hepatitis. At present, neither a vaccine nor any effective therapy is available. Multi-epitope DNA vaccine (minigenes/epigenes) is a novel nucleic acid vaccine which can induces high effective cellular and humoral immune responses and has good perspective in clearing Hepatitis C virus through screening and assembling optimal antigen epitope genes(T cell、B cell epitope included). It is advanced in covering more HCV subtypes, inducing comprehensive anti-HCV immune responses and reducing the negative influence caused by irrelevant, disturbing and suppressive sequence as far as possible through selecting the most potential protective epitopes in DNA vaccine design. The recent research progress on HCV compound multi-epitope DNA vaccine and future prospects were reviewed.

Key words： Hepatitis C virus Epitope DNA vaccine

Received: 31 October 2006 Published: 10 May 2010

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	YANG Hua-Jiang
	CAO Si-Cheng

Cite this article:

. Research Progress on Hepatitis C Virus Multi-epitope DNA Vaccine. China Biotechnology, 2007, 27(1): 119-125.

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https://manu60.magtech.com.cn/biotech/ OR https://manu60.magtech.com.cn/biotech/Y2007/V27/I1/119

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