[1] McCormick D. Two interconnected B vitamins: riboflavin and pyridoxine. Physiol Rev, 1989, 69:1170-1198.
[2] 尹光琳,战立克,赵根楠著.发酵工业全书.北京:中国医药科技出社,1992.237-248. Yi G L ,Zhan L K, Zhao G N. Book of Fermentation Industry. Beijing:Chinese Medical Science and Technology Press,1992.237-248.
[3] 童朝阳,徐琪寿.核黄素的药理作用及应用前景.军事医学科学院院刊,2003,27(3):223-226. Tong Z Y, Xu Q S.Bulletin of the Academy of Military Medical Sciences,2003, 27(3):223-226.
[4] Dalton S D, Rahimi A R. Emerging role of riboflavin in the treatment of nucleoside analogue-induced type B lactic acidosis. AIDS Patient Care STDS,2001,15:611-614.
[5] Stahmann K P, Revuelta J L, Seulberger H. Three biotechnical processes using Ashbya gossypii, Candida famata or Bacillus subtilis compete with chemical riboflavin production. Appl Microbiol Biotechnol, 2000, 53:509-516.
[6] Heefner D, Weaver C A, Yarus M J,et al. Riboflavin producing strains of microorganisms, method for selecting, and method for fermentation. Wo 09822,1988-06.
[7] Lee K H, Park Y H, Han J K, et al. Microorganism for producing riboflavin and method for producing riboflavin using the same. WO 050863 A1, 2004.
[8] Mironov A S, Korolkova N V, Errais L L, et al. Method for producing riboflavin.WO 046347 A1, 2004.
[9] Marcus S, Ajay S, Owen P W. Development in the use of Bacillus species for industrial production. Can J Microbiol,2004, 50:1-17.
[10] 武秋立. 重组枯草芽孢杆菌生产核黄素发酵优化及代谢组学研究.天津大学博士学位论文,天津:天津大学,2007. Wu Q L. Study on riboflavin fermentation optimization and metabolomics of recombinant Bacillus subtilis, Ph.D dissertation,Tianjin: Tianjin University, 2007.
[11] Bailey J E. Towards a science of metabolic engineering. American Association for the Advancement of Science,1991, 252:1668-1675.
[12] Stephanopulos G N, Aristidou A A, Nielsen J. Metabolic Engineering Principle and Methodologies. Academic Press,1998.
[13] Heinrich R, Schuster S. The modeling of metabolic systems: structure, control and optimality. Biosystems, 1998,47(1):61-77.
[14] Varner J, Ramkrishna D. Mathmatical modes of metabolic pathways. Curr Opin Biotechnol, 1999,10(2):146-150.
[15] Gombert A K, Nielsen J. Mathematical modeling of metabolism.Curr Opin Biotechnol, 2000,11(2):180-186.
[16] 李晓静,陈涛,陈洵,等. 13C代谢通量分析.化学进展,2006,18(7/8):995-1001. Li X J, Chen T, Chen X, et al.Progress in Chemistry,2006,18(7/8):995-1001.
[17] Lee S Y, Hong S H, Moon S Y. In silico metabolic pathway analysis and design: succinic acid production by metabolically engineered Escherichia coli as an example. Genome Inform, 2002,13:214-223.
[18] Bai D M, Zhao X M, Li X G, et al. Strain improvement and metabolic flux analysis in the wild-type and a mutant Lactobacillus lactis atrain for L(+)-lactic acid production. Biotechnol Bioeng, 2004, 88(6):681-689.
[19] 陈涛,王靖宇,周士奇,等. 基因组改组及代谢通量分析在产核黄素Bacillus subtilis性能改进中的应用. 化工学报, 2004,55(11):1842-1848. Chen T, Wang J Y, Zhou S Q, et al. Journal of Chemical Industry and Engineering, 2004,55(11):1842-1848.
[20] Zamboni N, Fischer E, Muffler A, et al. Transient expression and flux changes during a shift from high to low riboflavin production in continuous cultures of Bacillus subtilis. Biotechnol Bioeng, 2005, 89(2):219-232.
[21] Franzén C J. Metabolic flux analysis of RQ-controlled microaerobic ethanol production by Saccharomyces cerevisiae. Yeast, 2003, 20:117-132.
[22] Dunn W B, Ellis D I. Metabolomics: Current analytical platforms and methodologies. Trends Ana Chem, 2005, 24 (4):285-294.
[23] Wiback S J, Mahadevan R, Palsson B. Using metabolic flux data to further constrain the metabolic solution space and predict internal flux patterns: the Escherichia coli spectrum. Biotechnol Bioeng, 2004,86(3):317-331.
[24] Riascos C A M, Gombert A K, Pinto J M. A global optimization approach for metabolic flux analysis based on labeling balance. Compu Chem Eng, 2005, 29:447-458.
[25] Stulke J,Hillen W. Regulation of carbon catabolism in Bacillus species. Annu Rev microbial, 2000, 54:849-880.
[26] Dauner M, Sauer U. Stoichiometric growth model for riboflavin producing Bacillus subtilis. Biotechnol and Bioeng, 2001, 76 (2):132-143.
[27] Ludwig H, Rebhan N, Blencke H M, et al. Control of the glycolytic gapA operon by the catabolite control protein A in Bacillus subtilis: a novel mechanism of CcpA mediated regulation. Mol Microbiol, 2002, 45(2):543-553.
[28] Russell J B, Cook G M. Energetics of bacterial growth: balance of anabolic and catabolic reactions. Microbiol Rev, 1995, 59(1):48-62.
[29] Jense K F, Pederson S. Metabolic growth rate control in Escherchia coli may be a consequence of subsaturation of macromolecular apparatus with substrates and catalytic components. Microbiol Rev, 1990, 54:89-100.
[30] Van de Walle M, Shiloach J. Proposed mechanism of actete accumulation in two recombinant Escherichia coli strains during high density fermentation. Biotechnol Bioeng, 1998, 57(1):71-78.
[31] 马红武.由发酵实验数据和基因组信息基于计量关系分析代谢网络.天津大学博士论文,天津:天津大学,2001. Ma H W. Metabolic network analysis based on stoichiometric relations from the fermentation data and the genomic information . Ph.D dissertation, Tianjin:Tianjin University, 2001.
[32] Sauer U. Cameron D C, Baily J E. Metabolic capacity of Bacillus subtilis for the production of purine nucleosides, riboflavin, and folic acid. Biotechnol Bioeng, 1998, 59(2):227-238.
[33] 段云霞.产核黄素工程菌B. subtilis PY的代谢工程研究.天津大学博士论文,天津:天津大学,2008,73-85. Duan Y X. Metabolic engineering of Bacillus subtilis PY for riboflavin production. Ph.D dissertation, Tianjin:Tianjin University, 2008.73-85.
[34] Zhu Y B, Chen X, Chen T, et al. Enhancement of riboflavin production by overexpression of acetolactate synthase inapta mutant of Bacillus subtilis. FEMS Microbiol Lett, 2007,266: 224-230.
[35] Zamboni N. Metabolic engineering of respiration for improved riboflavin production and elucidation of NADPH metabolism in Bacillus subtilis. Ph.D dissertation,Zürich Switzerland,Swiss Federal Institute of Technology,2003.
[36] Trumpower B L, Gennis R B. Energy transduction by cytochrome complexes in mitochondrial and bacterial respiration: The enzymology of coupling electron transfer reactions to transmembrane proton translocation. Annu Rev Biochem,1994,63:675-716.
[37] Sauer U, Bailey J E. Estimation of P-to-O ration in Bacillus subtilis and its influence on maximum riboflavin yield. Biotechnol Bioeng, 1999, 64:750-754.
[38] Dauner M, Storni T, Sauer U. Bacillus subtilis metabolism and energetics in carbon-limited and excess-carbon chemostat culture. J Bacteriol, 2001,183(24):7308-7317.
[39] Zamboni N, Mouncey N, Hohmann H P, et al. Reducing maintenance metabolism by metabolic engineering of respiration improves riboflavin by Bacillus subtilis. Metab Eng, 2003,5:49-55.
[40] 李晓静. 枯草芽孢杆菌核黄素操纵子及呼吸链的代谢工程改造.天津大学博士论文,天津:天津大学,2006. Li X J. Metabolic engineering of riboflavin operon and respiratory chain of Bacillus subtilis. Ph.D dissertation, Tianjin: Tianjin University, 2006.
[41] Dauner M,Sauer U. Stiochiometric growth model for riboflavin producing Bacillus subtilis. Biotechnol and Bioeng, 2001, 76 (2):132-143.
[42] Li X J, Chen T, Chen X, et al. Redirection electron flow to high coupling efficiency of terminal oxidase to enhance riboflavin biosynthesis. Appl Microbiol Biotechnol,2006,73:374-383.
[43] Burrows R B. Presence in E.coli of deaminase and reductase involved in biosynthesis of riboflavin. J Bacteriol, 1978, 136 (2): 657-667.
[44] Hümbelin M , Griesser V , Keller T, et al. GT Pcyclohydrolase II and 3,4-dihydroxy-2-butanone 4-phosphate synthase are rate-limiting enzymes in riboflavin synthesis of an industrial Bacillus subtilis strain used for riboflavin production. J Ind Microbiol Biotechnol, 1999, 22: 1-7.
[45] Sauer U, Hatzimanikatis V, Bailey J E, et al. Metabolic fluxes in riboflavin-producing Bacillus subtilis. Nat Biotechnol, 1997, 15:448-452.
[46] Stepanov G. Production of riboflavin by bacteria. French patent, 2546907,1984-12.
[47] Chen Xun. New approaches to construction of recombinant strains-riboflavin producers. Ph.D dissertation, MOSCOW,State Scientific Research Institute of Genetics and Selection of Industrial Microorganisms,1997.
[48] Chen T, Chen X, Wang J Y, et al. Effect of riboflavin operon dosage on riboflavin productivity in Bacillus subtilis. Transactions of Tianjin University, 2005, 11(1):1-5.
[49] Perkins J B, Sloma A, Hermann T, et al. Genetic engineering of Bacillus subtilis for the commercial production of riboflavin. J Ind Microbiol Biotechnol, 1999, 22:8-18.
[50] Duan Y X, Chen T, Chen X, et al. Enhanced riboflavin production by expressing heterologous riboflavin operon from B.cereus ATCC14579 in Bacillus subtilis. Chinese Journal of Chemical Engineering, 2010,18(1):129-136.
[51] Zamboni N, Fischer E, Laudert D, et al. The Bacillus subtilis yqjI gene encodes the NADP+-dependent 6-P-gluconate dehydrogenase in the pentose phosphate pathway. J Bacteriol, 2004,14:4528-4534.
[52] Moszer I, Jones LM, Moreira S, et al. SubtiList: the reference database for the Bacillus subtilis genome. Nucleic Acids Res, 2002, 30(1):62-65.
[53] Duan Y X, Chen T, Chen X, et al. Overexpression of glucose-6-phosphate dehydrogenase enhances riboflavin production in Bacillus subtilis.Appl Microbiol Biotechnol,2010,85:1907-1914.
[54] Zamboni N, Fischer E, Muffler A, et al. Transient expression and flux changes during a shift from high to low riboflavin production in continuous cultures of Bacillus subtilis. Biotechnol. Bioeng,2005,89(2):219-232.
[55] Zhu Y B, Chen X, Chen T, et al. Over-expression of glucose dehydrogenase improves cell growth and riboflavin production in Bacillus subtilis. Biotechnol Lett ,2006, 28:1667-1672.
[56] Shi S B, Shen Z, Chen X, et al. Increased production of riboflavin by metabolic engineering of the purine pathway in Bacillus subtilis.Biochemical Engineering Journal, 2009, 46:28-33.
[57] Shi S B, Chen T, Chen X, et al. Enhancing riboflavin production by genetic modification of purine pathway in Bacillus subtilis.Journal of Biotechnology, 2008, 136S:35.
[58] 陈涛.基于基因组重排的产核黄素枯草芽孢杆菌的代谢工程.天津大学博士论文,天津:天津大学,2004. Chen T. Trait improvement of riboflavin-producing Bacilus subtilis by genome shuffling and metabolic flux analysis . Ph.D dissertation,Tianjin: Tianjin University, 2004.
[59] Perkins J B, Alan S, Janiee G P, et al. Bacterial strains which overproduced riboflavin.US patent, 5925538,1999.
[60] Perkins J B, Pero J G, Sloma A. Riboflavin overproducing strains of bacteria. European patent application 0405370,1991-01.
[61] Winkler W C,Cohen-chalamish, Breaker R R. An mRNA structure that controls gene expression by binding FMN. Proc Natl Acad Sci, 2002, 99(25): 15908-15913.
[62] Solovieva M, Kreneva R A, Leak D J, et al. The ribR gene encodes a monofunctional riboflavin kinase which is involved in regulation of the Bacillus subtilis riboflavin operon. Microbiol, 1999, 145:67-73.
[63] Mandal M, Boese B, Barrick J E, et al. Riboswitches control fundamental biochemical pathways in Bacillus subtilis and other bacteria. Cell, 2003, 113(5): 577-586.
[64] Coquard D. Molecular cloning and characterisation of the ribC gene from Bacillus subtilis: a point mutation in ribC results in riboflavin overproduction. Mol Gen Genet,1997,254:81-84.
[65] 张会图,姚斌,范云六.核黄素基因工程研究进展,中国生物工程杂志,2004,24(12):32-38. Zhang H T,Yao B,Fan Y L.China Biotechnology,2004,24(12):32-38.
[66] Mironov A S, Gusarov I, Rafikov R, et al. Sensing small molecules by nascent RNA:a mechanism to control transcription in bacteria.Cell,2002,111(5):747-756. |