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中国生物工程杂志

China Biotechnology
China Biotechnology  2010, Vol. 30 Issue (10): 60-65    DOI:
    
Development of Potential Therapeutics Targeting to Human Toll-like Receptor
XING Ya-ling, REN Le-ning, CHEN Xiao-juan, CHEN Zhong-bin
Division of Infection and Immunity, Department of Electromagnetic and Laser Biology, Beijing Institute of Radiation Medicine, Beijing 100850, China
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Abstract  

Innate immune initiates at recognition of broad classes of conserved microbial molecular structures known as pathogen-associated molecular patterns (PAMPs) by a diverse set of germ line-encoded receptors, termed pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs). TLRs are one of the largest and best studied families of PRR. TLRs activate innate immunity pathway, regulate the secretion of cytokines such as TNF-α, ILs and IFN-α, and ultimately modulate the function of immunity system. Over ten TLRs have been discovered in human genome that may be the therapy targets for cancer, viral and bacterial infection, inflammation, autoimmunity and radiation injury. Several compounds targeting TLRs are now undergoing preclinical or clinical evaluation, including anti-tumor drugs, anti-virus drugs, anti-infection drugs and anti-radiation drugs. The structural feature of TLRs, the characteristics of their signaling pathways, and the development status of related compounds for therapeutic manipulation were summarized.



Key wordsToll-like receptor      Anti-tumor drug      Anti-virus drug      Anti-radiation drug      Immunotherapy     
Received: 10 June 2010      Published: 25 October 2010
ZTFLH:  Q819  
Corresponding Authors: CHEN Zhong-bin     E-mail: chenzhongbin@yahoo.com;chenzb@bmi.ac.cn
Cite this article:

XING Ya-ling, REN Le-ning, CHEN Xiao-juan, CHEN Zhong-bin. Development of Potential Therapeutics Targeting to Human Toll-like Receptor. China Biotechnology, 2010, 30(10): 60-65.

URL:

https://manu60.magtech.com.cn/biotech/     OR     https://manu60.magtech.com.cn/biotech/Y2010/V30/I10/60


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