中国生物工程杂志

Recently tumor protein D52-like proteins, the first member of which was found in human breast carcinoma, attract increasing research interests. All D52-like proteins are small coil-coil motif bearing proteins which are conserved from lower organism to human being and among the same species. Alternative splicing is producing numbers of isoforms which play different function roles．D52-like genes amplify in multicarcinoma，with the protein expression increasing．The diverse functions of D52-like proteins, which may concern with human disease including cancer, and how they play in vital are not clear so far. Further studies may highlight their function and the mechanism them work.