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Progress in research on HIV-1 integrase and its inhibitors |
Li Fang-Qiong ZHAN Jin-Biao |
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Abstract HIV-1 integrase enzyme is a 32 KDa protein encoded by HIV pol gene. It is responsible for integration of viral cDNA into host chromosomal DNA, which is indispensable for HIV replication.Since there was no functional equivalent for this enzyme in human cells, inhibition of integrase will bring little side effect to human body. Thus HIV integrase has become an attractive and rational target for therapy of AIDS after reverse transcriptase and protease. This review focuses on the recent research on HIV integrase structure ,inhibitors and also new therapeutic method target at HIV-1 integrase.
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Received: 11 October 2007
Published: 25 January 2008
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Corresponding Authors:
ZHAN Jin-Biao
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