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中国生物工程杂志

China Biotechnology
China Biotechnology  2008, Vol. 28 Issue (1): 80-86    DOI:
    
Progress in research on HIV-1 integrase and its inhibitors
Li Fang-Qiong ZHAN Jin-Biao
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Abstract  

HIV-1 integrase enzyme is a 32 KDa protein encoded by HIV pol gene. It is responsible for integration of viral cDNA into host chromosomal DNA, which is indispensable for HIV replication.Since there was no functional equivalent for this enzyme in human cells, inhibition of integrase will bring little side effect to human body. Thus HIV integrase has become an attractive and rational target for therapy of AIDS after reverse transcriptase and protease. This review focuses on the recent research on HIV integrase structure ,inhibitors and also new therapeutic method target at HIV-1 integrase.



Key wordshuman immunodeficiency virus-1      integrase      inhibitor      RNA interference     
Received: 11 October 2007      Published: 25 January 2008
ZTFLH:  Q78  
Corresponding Authors: ZHAN Jin-Biao   
Cite this article:

Li Fang-Qiong ZHAN Jin-Biao. Progress in research on HIV-1 integrase and its inhibitors. China Biotechnology, 2008, 28(1): 80-86.

URL:

https://manu60.magtech.com.cn/biotech/     OR     https://manu60.magtech.com.cn/biotech/Y2008/V28/I1/80

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