Molecular Mechanism of Hyaluronan Biosynthesis in Streptococci and Construction of Engineering Strains

China Biotechnology

2008, Vol. 28

Issue (4): 98-102 DOI:

Molecular Mechanism of Hyaluronan Biosynthesis in Streptococci and Construction of Engineering Strains

Download:

HTML

PDF(435KB) HTML
Export: BibTeX | EndNote (RIS)

Abstract

Hyaluronic acid (HA) is a linear polysaccharide chain composed of alternating β-1,4-glucuronic acid (GlcA) and β-1,3-N-acetylglucosamine (GlcNAc) moieties. Construction of engineering strain has become the prevailing strategy for increasing yield and improving its quality, especially the molecular weight. Here the molecular mechanism of HA biosynthesis in Streptococcus strains was reviewed, involving fermentation strains, operon structure, crucial enzyme and construction of engineering strains. In addition, the prevalent problems in HA fermentation production were also discussed and the protocols were tentatively put forward for the upcoming research and industrial production.

Key words： hyaluronic acid biosynthesis construction of engineering strain fermentation

Received: 06 December 2007 Published: 25 April 2008

	Service
	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors

Cite this article:

. Molecular Mechanism of Hyaluronan Biosynthesis in Streptococci and Construction of Engineering Strains. China Biotechnology, 2008, 28(4): 98-102.

URL:

https://manu60.magtech.com.cn/biotech/ OR https://manu60.magtech.com.cn/biotech/Y2008/V28/I4/98

[1]	ZHANG Heng,LIU Hui-yan,PAN Lin,WANG Hong-yan,LI Xiao-fang,WANG Tong,FANG Hai-tian. Research Strategy for Biosynthesis of Gamma Aminobutyric Acid[J]. China Biotechnology, 2021, 41(8): 110-119.

[2]	LI Bing,ZHANG Chuan-bo,SONG Kai,LU Wen-yu. Research Progress in Biosynthesis of Rare Ginsenosides[J]. China Biotechnology, 2021, 41(6): 71-88.

[3]	MIAO Yi-nan,LI Jing-zhi,WANG Shuai,LI Chun,WANG Ying. Research Progress of Key Enzymes in Terpene Biosynthesis[J]. China Biotechnology, 2021, 41(6): 60-70.

[4]	ZHAI Jun-ye,CHENG Xu,SUN Ze-min,LI Chun,LV Bo. Current Advances in Biosynthesis of Acteoside[J]. China Biotechnology, 2021, 41(5): 94-104.

[5]	GAO Yin-ling,ZHANG Feng-jiao,ZHAO Gui-zhong,ZHANG Hong-sen,WANG Feng-qin,SONG An-dong. Research Progress of Itaconic Acid Fermentation[J]. China Biotechnology, 2021, 41(5): 105-113.

[6]	GUO Er-peng, ZHANG Jian-zhi, SI Tong. Recent Advances in the High-throughput Engineering of Lanthipeptides[J]. China Biotechnology, 2021, 41(1): 30-41.

[7]	LIU Xiao-chen, FAN Dai-di, YANG Fan, WU Zhan-sheng. Advances in Microbial Production of Ginsenoside and Its Derivatives[J]. China Biotechnology, 2021, 41(1): 80-93.

[8]	WANG Guang-lu, WANG Meng-yuan, ZHOU Yi-fei, MA Ke, ZHANG Fan, YANG Xue-peng. Research Progress in Pyrrologuinoline Quinone Biosynthesis[J]. China Biotechnology, 2021, 41(1): 103-113.

[9]	DUAN Hai-rong,WEI Sai-jin,LI Xun-hang. *Advances in Rhamnolipid Biosynthesis by Pseudomonas aeruginosa* Research**[J]. China Biotechnology, 2020, 40(9): 43-51.

[10]	DENG Ting-shan,WU Guo-gan,SUN Yu,TANG Xue-ming. Advances in Biosynthesis of Phenyllactic Acid[J]. China Biotechnology, 2020, 40(9): 62-68.

[11]	YAN Wei-huan,HUANG Tong,HONG Jie-fang,MA Yuan-yuan. Recent Advances in Butanol Biosynthesis of Escherichia coli[J]. China Biotechnology, 2020, 40(9): 69-76.

[12]	YANG Na,WU Qun,XU Yan. Fermentation Optimization for the Production of Surfactin by Bacillus amyloliquefaciens[J]. China Biotechnology, 2020, 40(7): 51-58.

[13]	WANG Meng,ZHANG Quan,GAO Hui-peng,GUAN Hao,CAO Chang-hai. Research Progress on the Biological Fermentation of Xylitol[J]. China Biotechnology, 2020, 40(3): 144-153.

[14]	WANG Bao-shi,TAN Feng-ling,LI Lin-bo,LI Zhi-gang,MENG Li,QIU Li-you,ZHANG Ming-xia. Biological Treatment Strategy Improves the Bio-accessibility of Bran Phenols[J]. China Biotechnology, 2020, 40(12): 88-94.

[15]	Meng-ying OU,Xiao-zheng WANG,Shuang-jun LIN,Tong-wei GUAN,Yi-jin LIN. A Review of Studies on Streptonigrin[J]. China Biotechnology, 2019, 39(7): 100-107.

Viewed

Full text

Abstract

Cited

Shared

Discussed