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| Research Progress on Centrosome Cycle Related Protein Phosphorylation/Dephosphorylation and the Involved Functions |
| TAN Tan1,3, LIANG Qian-jin1,2 |
1. College of Life Sciences, Beijing Normal University/Beijing Key Lab of Gene Engineering Drugs & Biological Technology, Beijing 100875, China;
2. College of Life Sciences, Beijing Normal University/Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, Beijing 100875, China;
3. College of Life Sciences, Beijing Normal University/Beijing Key Lab of Gene Resource and Molecular Development, Beijing 100875, China |
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Abstract Centrosome is a significant organelle without membrane in animal cells and some lower plant cells. Normally, centrosomes participate cell division (mitosis), form spindle which is based on microtubules and then pull the duplicated chromosomes to the opposite poles of the cell. This process ensures that genetic materials (DNA) can pass from one generation to the next accurately, orderly and perfectly. Like other essential organelles related with cell division and proliferation, the behavior and regulation of centrosome also depends on many function-related proteins. In these proteins, one part connects with centrosome duplication and separation, ensuring centrosome cycle achieved; the other part, not only associates with cell cycle and centrosome, but also plays vital roles in other aspects. Regardless of normal cells or abnormal cells (e. g. tumour cells), protein modifications, especially the phosphorylation modification, dominate in cell regulation. As one kind of the major organelles cells, centrosome contains many centrosomal proteins depend on phosphorylation regulation. To provide references for future research, the centrosome cycle related protein phosphorylation and function were reviewed.
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Received: 23 April 2012
Published: 25 November 2012
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