|
|
|
| New Progress on Methods of Transgenic Animal and Animal Product Safety Assessment |
| YU Qian1, ZHAO Er-hu1, CAO Li-jing2, ZHAO Qian1, ZHAO Yong-ju 1 |
1. College of Animal Science and Technology, Chongqing Key Laboratory of Forage & Herbivore, Chongqing Engineering Research Centre for Herbivores Resource Protection and Utilization, Southwest University, Chongqing 400716, China;
2. Rongchang Vocational Education Center, Chongqing 402060, China |
|
|
|
Abstract Recent years, transgenic animal technologies have been developed rapidly and been used widely in many fields, such as food, medicine, agriculture and biomaterial. The security issues of transgenic animals and their products on public and environmental safety are increasingly emerged with the enormous economic and social benefits produced. "Substantial equivalence principle" is one of the basic principles in security evaluation of transgenic animals world widely. It elaborates from three aspects, the security assessment of transgenic animals and their products which are as foods and medicines, the assessment of eco-environmental safety and effect of transgenic animals, and the assessment of undesired effects, which are conducive to the establishment of transgenic animals evaluation system in China.
|
|
Received: 12 April 2012
Published: 25 October 2012
|
|
|
|
|
[1] Palmiter R D, Brinster R L, Hammer R E, et al. Dramatic growth of mice that develop from eggs micro injected with a metallothione in growth hormone fusion gene. Nature, 1982, 300(5893): 611-615.
[2] Kelly L. The safety assessment of foods from transgenic and cloned animals using the comparative approach, Rev Sci Tech Offint Epiz, 2005, 24(1): 61-74.
[3] Codex Alimentarius Commission.Principles for the risk analysis of foods derived from modern biotechnology. 2003. 44.
[4] Codex Alimentarius Commission. Guideline for the conduct of food safety assessment of foods derived from recombinant-DNA animals.2008.68.
[5] Cellini F, Chesson A, Colquhoun I, et al.Unintended effects and their detection in genetically modified crops.Food and Chemical Toxicology, 2004, 42(7):1089-1125.
[6] 徐俊锋,陈笑芸,孙彩霞.转基因动物及其食品安全性评估方法.食品科学,2010,31 (05):302-306. Xu J F, Cheng X Y, Sun C X. Transgenic animals and corresponding food safety assessment methods.Food Science, 2010, 31 (5): 302-306.
[7] Lema M A, Burachik M.Safety assessment of food products from rDNA animals.Comp Immunol Microbiol Infect Di, 2009, 32 (2): 163-189.
[8] Kleter G A, Kok E J.Safety assessment of biotechnology used in animal production, including genetically modified (GM) feed and GM animals.Animal Science Papers and Reports, 2010,28(2):105-114.
[9] Delvlin R H, Yesaki T Y, Donaldson E, et a1.Transmission and phenotypie effects of an antifreeze/GH gene construct in coho salmon (Oncorhynchus kisutch).Aquaculture, 1995, 137(1-4): 161-169.
[10] Kochhar H P, Evans B R.Current status of regulating biotechnology-derived animals in Canada-animal health and food safety considerations.Theriogenology, 2007 67(1):188-197.
[11] 姚玉昌, 韩红兵, 刘玉峰,等. 转TLR4基因绵羊血液生化指标的检测分析. 第六次全国动物生物技术学术研讨会. 呼和浩特:中国农业生物技术学会,2011. 261. Yao Y C, Han H B, Liu Y F, et al. TLR4 transgenic sheep blood biochemical parameters detection analysis. the 6th National Annual Conference for Animal Biotechnology. Hohhot: Institute of Animal Biotechnology, 2011. 261.
[12] 乔娜, 陈建泉, 徐旭俊等. 转基因对山羊的生长发育、生理生化和繁殖性能的影响. 第六次全国动物生物技术学术研讨会. 呼和浩特:中国农业生物技术学会, 2011. 266. Qiao N, Chen J Q, Xu X J, et al. Effect of transgene on growth,physiology-biochemistry and reproductive performance in goats. the 6th National Annual Conference for Animal Biotechnology. Hohhot: Institute of Animal Biotechnology, 2011. 266.
[13] 玄立杰,谢英添. 转基因食品安全问题及其评价体系. 安徽农业科学, 2010, 38(25):14175-14177. Xuan L J, Xie Y T. The safety and safety assessment of genetically modified foods. Journal of Anhui Agricultural Sciences, 2010, 38(25): 14175-14177.
[14] 王二先,徐旭俊,苗晋锋等.转人乳铁蛋白基因山羊乳对大鼠生长及代谢机能的影响.南京农业大学学报, 2011, 34(2):119-123. Wang E X, Xu X J, Miao J F, et al. Effect of transgenic human lactoferrin goats’ milk on growth and metabolic performance in rats. Journal of Nanjing Agricultural University, 2011, 34(2):119-123.
[15] Nordlee J A, Taylor S L, Townsend J A, et al.Identification of a Brazil-Nut allergen in transgenic oybeans. NEJM, 1996, 334 (11): 688-692.
[16] FAO/WHO.Evaluation of allergenicity of genetically modified foods.Report of a joint FAO/WHO expert consultation on allergenicity of foods derived from biotechnology. Rome: Food and Agriculture Organization of the United Nations, 2001:1-29.
[17] Steven G. Sequence databases for assessing the potential allergenicity of proteins used in transgenic foods. Adv Food Nutr Res, 1998, 42: 63-92.
[18] 向钱, 李宁.食品致敏性研究进展. 国外医学卫生学分册, 2006, 33(06): 376-380. Xiang Q, Li N. New progress on the allergenicity of foods.Foreign Medical Sciences-hygine, 2006, 33(6): 376-380.
[19] Taylor S L, Lehrer S B. Principles and characteristics of food allergens. Critical Reviews In Food Science And Nutrition, 1996, 36(1): 91-118.
[20] Astwood J D, Leach J N, Roy L F. Stability of food allergens to digestion in vitro. Nature Biotechnol, 1996, 14: 1269-1273.
[21] Shagger H, Von Jagow H. Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for separation of proteins in the range from 1 to 100 kDa. Anal Biochem, 1987, (166): 368-379.
[22] Prescott V E, Hogan S P. Genetically modified plants and food hypersensitivity diseases:usage and implications of experimental models for risk assessment. Pharmacol Ther, 2006, 111 (02): 374-383.
[23] 佟广香, 匡友谊, 梁利群等. 转基因鲤的生态安全检测.吉首大学学报(自然科学版), 2010, 31(01): 96-103. Tong G X, Kuang Y Y, Liang L Q, et al. Evaluation of the ecological safety of transgenic CARP by AFLP. Journal of Jishou University (Natural Sciences Edition), 2010, 31(01): 96-103.
[24] Xu J X, Zhao J, Zhao Y F, et al. Molecular-based environmental risk assessment of three varieties of genetically engineered cows. Transgenic Res doi: 10.1007/s11248-010-9477-3.
[25] 赵杰,许建香,王建武,等. 转人溶菌酶猪环境安全评价. 动物遗传育种研究最新进展—第十六次全国动物遗传育种学术讨论会论文集. 扬州:中国畜牧兽医学会,2011. 211. Zhao J, Xu J X, Wang J W, et al. The environmental risk assessment of hLYZ transgenic pigs. Recent Advances in Animal Genetic and Breeding Research—the 16th National Annual Conference for Animal Genetic and Breeding. Yangzhou: Chinese Association of Animal Science and Veterinary Medicine, 2011. 211.
[26] 辛磊磊. 转植酸酶基因和抗粘液病毒基因猪环境安全评价. 北京:中国农业科学院,2011. Xin L L. Environment safety assessment of appA and MX1 cotransgenic pigs. Beijing: Chinese Academy of Agricultural Sciences, 2011.
[27] Tang M X, Zheng X M, Cheng W K, et al. Safety assessment of sFat-1 transgenic pigs by detecting their co-habitant microbe in intestinal tract. Transgenic Res doi: 10.1007/s11248-010-9457-7.
[28] 赵二虎, 王勇, 赵永聚,等. 转基因小鼠模型环境释放安全性评价初步研究. 第六次全国动物生物技术学术研讨会. 呼和浩特:中国农业生物技术学会, 2011. 271. Zhao E H, Wang Y, Zhao Y J, et al. Preliminary study on the environmental risk assessment of transgenic mice.the 6th National Annual Conference for Animal Biotechnology. Hohhot: Institute of Animal Biotechnology, 2011. 271.
[29] 王趁芳. 利用转基因小鼠模型进行转基因动物安全评价研究. 北京:中国农业科学院, 2008. Wang C F. The research of safety assessment on transgenic animal by transgenic mice model. Beijing: Chinese Academy of Agricultural Sciences, 2008. |
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
| |
Shared |
|
|
|
|
| |
Discussed |
|
|
|
|
