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中国生物工程杂志

China Biotechnology
China Biotechnology  2012, Vol. 32 Issue (04): 110-116    DOI:
    
tRNase Z’s Research Progress
HAN Yan, HUANG Yuan, YE Hai-yan
College of Life Science, Shanxi Normal University, Xi’an 710062, China
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Abstract  

tRNase Z is an endonuclease that catalyzes tRNA 3'-end processing in many bacteria, most eukaryotes and all archaea. tRNase Z generates a mature tRNA ending with the 3'-OH of the discriminator nucleotide and a trailer sequence with a 5'-phosphate from CCA-less tRNA precursors, which is absolutely essential for the addition of the CCA sequence, tRNA aminoacylation and protein synthesis. tRNase Z enzymes belong to the superfamily of metallo-β-lactamases. tRNase Z exists the short (tRNase ZS) and long (tRNase ZL) forms. tRNase Z has many functions, such as RNA 3'-end processing, guiding the positioning of protein, rRNA-processing, complementation with the REX2 gene, regulation of cell proliferation and differentiation etc. Further analysis of the function and properties of tRNase Z will play a potential and actual role in the treatment of AIDS and prostate cancer in the coming years.



Key wordstRNase Z      Metallo-β-lactamases(MBL)superfamily      3'-CCA      ELAC2     
Received: 14 December 2011      Published: 25 April 2012
ZTFLH:  Q55  
Cite this article:

HAN Yan, HUANG Yuan, YE Hai-yan. tRNase Z’s Research Progress. China Biotechnology, 2012, 32(04): 110-116.

URL:

https://manu60.magtech.com.cn/biotech/     OR     https://manu60.magtech.com.cn/biotech/Y2012/V32/I04/110


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