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中国生物工程杂志

China Biotechnology
China Biotechnology  2011, Vol. 31 Issue (7): 114-120    DOI:
    
Progress on the Plasticity of Muscle-derived Stem Cell
WU Xiao-yun, WANG Shi-li
Key Laboratory of Biotech-Drugs, Ministry of Health, Shandong Medicinal Biotechnology Center, Jinan 250062, China
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Abstract  

Two types of stem cells in muscle: satellite cells and muscle-derived stem cells (MDSCs) have been identified. MDSCs, a predecessor of the satellite cell, are considered to possess a higher regeneration capacity and to exhibit better cell survival and a broader range of multilineage capabilities. MDSCs are not only able to differentiate into mesodermal cell types including the myogenic, adipogenic, osteogenic, chondrogenic, endothelial, and hematopoietic lineages, but also possess the potential to break germ layer commitment and differentiate into ectodermal and endodermal lineages under certain conditions. The progress on isolation, identification, plasticity, and the current clinical applications of MDSCs are reviewed.



Key wordsMuscle-derived stem cells      Plasticity      Isolation      Differentiation      Gene therapy      Tissue regeneration     
Received: 21 September 2010      Published: 25 July 2011
ZTFLH:  Q2  
Cite this article:

WU Xiao-yun, WANG Shi-li. Progress on the Plasticity of Muscle-derived Stem Cell. China Biotechnology, 2011, 31(7): 114-120.

URL:

https://manu60.magtech.com.cn/biotech/     OR     https://manu60.magtech.com.cn/biotech/Y2011/V31/I7/114


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