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中国生物工程杂志

China Biotechnology
China Biotechnology  2011, Vol. 31 Issue (5): 113-120    DOI:
    
Research on HIV Entry Inhibitors
ZHANG Hao-yuan, WU Wen-yan
College of Life Sciences, Sun Yat-sen University,Guangzhou 510275, China
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Abstract  

In recent years, various kinds of HIV entry inhibitors have been invented with the discovery of the HIV entry process. They are divided into three main classes: attachment inhibitors, co-receptor binding inhibitors, and fusion inhibitors. The mechanism of action and structure of several important inhibitors are discussed. Many inhibitors are in advanced clinical trials. Especially, the fusion inhibitor T20 has been approved for the treatment of the HIV infected patients with other antiretroviral therapys,by FDA,in 2003 and the CCR5 inhibitor maraviroc has been approved by FDA, in 2007.



Key wordsHIV      Inhibitor      Viral entry     
Received: 21 December 2010      Published: 27 May 2011
ZTFLH:  Q81  
Cite this article:

ZHANG Hao-yuan, WU Wen-yan. Research on HIV Entry Inhibitors. China Biotechnology, 2011, 31(5): 113-120.

URL:

https://manu60.magtech.com.cn/biotech/     OR     https://manu60.magtech.com.cn/biotech/Y2011/V31/I5/113


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