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中国生物工程杂志

China Biotechnology
China Biotechnology  2011, Vol. 31 Issue (06): 111-115    DOI:
    
Macromolecule Modified Adenovirus as Vector for Gene Therapy
WEI Lin1,2, QIU Fei1,2, DIAO Yong1,2
1. Institute of Molecular Medicine, Huaqiao University, Quanzhou 362021, China;
2. Engineering Research Center of Molecular Medicine, Ministry of Education, Quanzhou 362021, China
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Abstract  

Adenovirus is a kind of virus vector which is used widely in gene therapy, especially in treating cancer and heredopathia. However, its non-specificity and high immunogenicity have inhibited its application in clinical. Virus which modified with macromolecular to the capsid of virus through covalently conjugate or electrostatic interaction have lower immunogenicity and high tropism, and the modifications have little effect in their gene transduction efficacy. It is becoming an important modification method in adenovirus. The progress of modified adenovirus with polymers were reviewed.



Key wordsAdenovirus vector      Polymer      Target      Immunogenicity     
Received: 30 January 2011      Published: 28 June 2011
ZTFLH:  Q819  
Corresponding Authors: Fei QIU     E-mail: qiufei@hqu.edu.cn
Cite this article:

WEI Lin, QIU Fei, DIAO Yong. Macromolecule Modified Adenovirus as Vector for Gene Therapy. China Biotechnology, 2011, 31(06): 111-115.

URL:

https://manu60.magtech.com.cn/biotech/     OR     https://manu60.magtech.com.cn/biotech/Y2011/V31/I06/111

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