Advances on Heterogenous Expression of Lactoferrin Towards Antimicrobial Role

China Biotechnology

2011, Vol. 31

Issue (03): 107-112 DOI:

Advances on Heterogenous Expression of Lactoferrin Towards Antimicrobial Role

BAI Xue-jing, YANG Ya-lin, TENG Da, WANG Jian-hua

Key Laboratory of Feed Biotechnology of MOA, Gene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081,China

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Abstract

Lactoferrin is a key component of the mammalian immune defense system. It shows a multifunction involving in iron regulation, broad spectrum of antimicrobial activity, anti-inflammatory activity, anti-tumor activity and immunologic enhancement. But its potential nutritional and therapeutic applications have been limited due to the high cost for extraction and purification of functional lactoferrin from milk. Recombinant expression would be a feasible approach to produce active lactoferrin in large scale. The advances of lactoferrin recombinant expression in E. coli, yeast, insect, plant and mammalian cells were reviewed.

Key words： Lactoferrin Recombinant Expression

Received: 25 September 2010 Published: 01 April 2011

ZTFLH:

Q78

Corresponding Authors: Jianhua WANG E-mail: jhwangfribio@yahoo.com.cn

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Cite this article:

BAI Xue-jing, YANG Ya-lin, TENG Da, WANG Jian-hua. Advances on Heterogenous Expression of Lactoferrin Towards Antimicrobial Role. China Biotechnology, 2011, 31(03): 107-112.

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https://manu60.magtech.com.cn/biotech/ OR https://manu60.magtech.com.cn/biotech/Y2011/V31/I03/107


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