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中国生物工程杂志

China Biotechnology
China Biotechnology  2011, Vol. 31 Issue (02): 116-123    DOI:
    
Research Advancement on Biosynthesis and Degradation of Zearalenone
LU Zi-xian, WU Song-ling, SUN Chang-po
Academy of State Administration of Grain, Beijing 100037, China
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Abstract  

After zearalenone (ZON) and its six derivatives are introduced,its biosynthesis pathway is described. Genetic organization of ZON biosynthetic gene cluster is not only depicted but expression style of the gene cluster is illuminated as well. It is discussed how inactivation and degradation of ZON occurs. Application of ZON hydrolase on genetic engineering is summarized and several proposals for ZON degradation with biotechnology in future are also put forward.



Key wordsZearalenone (ZON)      Derivative      Biosynthesis and degradation      Genetic engineering      Detoxification     
Received: 16 July 2010      Published: 18 February 2011
ZTFLH:  Q819  
Corresponding Authors: Zixian Lu     E-mail: lzx@chinagrain.org
Cite this article:

LU Zi-xian, WU Song-ling, SUN Chang-po. Research Advancement on Biosynthesis and Degradation of Zearalenone. China Biotechnology, 2011, 31(02): 116-123.

URL:

https://manu60.magtech.com.cn/biotech/     OR     https://manu60.magtech.com.cn/biotech/Y2011/V31/I02/116

[1] Golinski P, Vesonder R F, Latus-Zietkiewicz D, et al. Formation of fusarenone X, nivalenol, zearalenone, α-trans-zearalenol, β-trans-zearalenol, fusarin C by Fusarium crookwellense. Applied and Environmental Microbiology, 1988, 54(8):2147-2148.
[2] Ichinoe M, Kurata H, Sugiura Y, et al. Chemotaxonomy of Gibberella zeae with reference to production of trichothecenes and zearalenone. Applied and Environmental Microbiology, 1983, 46(6):1364-1369.
[3] Abbas H K, Mirocha C J, Meronuck R A, et al. Mycotoxin and Fusarium spp. Associated with infected ear of corn in Minnesota. Applied and Environmental Microbiology, 1988, 54(8):1930-1933.
[4] Bosch U, Mirocha C J. Toxin production by Fusarium species from sugar beets and natural occurrence of zearalenone in beets and beet fibers. Applied and Environmental Microbiology, 1992, 58(10):3233-3239.
[5] Xiong K, Hu W, Wang M, et al. A survey on contamination of deoxynivalenol and zearalenol in maize and wheat from Anhui and Henan province. Food Science, 2009,30:(20) 265-268.
[6] Plasencia J, Mirocha C J. Isolation and characterization of zearalenone sulfate produced by Fusarium spp. Applied and Environmental Microbiology, 1991, 57(1) :146-150.
[7] Hagler W M, Mirocha C J, Pather S V, et al. Identification of the naturally occurring isomer of zearalenol produced by Fusarium roseum 'Gibbosum’ in rice culture. Applied and Environmental Microbiology, 1979, 37(5):849-853.
[8] Hagler W M, Mirocha C J. Biosynthesis of zearalenone from acetate by Fusarium roseum 'Gibbosum’. Applied and Environmental Microbiology, 1980, 39(3):668-670.
[9] Pathre S V, Khadikar P V, Mirocha C J. Biosynthesis of zearalenone: a simple and efficient method to incorporate acetate label by using solid cultures. Applied and Environmental Microbiology, 1989, 55(8):1955-1956.
[10] Gaffoor I, Trail F. Characterization of two polyketide synthase genes involved in zearalenone biosynthesis in Gibberella zeae. Applied and Environmental Microbiology, 2006, 72(3):1793-1799.
[11] Richardson K E, Hagler W M, Hamilton PB. Bioconversion of α-zearalenol and β-zearalenol into zearalenone Fusarium roseum 'Gibbosum’. Applied and Environmental Microbiology,1984, 47:1206-1209.
[12] Kim Y T, Lee Y R, Jin J, et al. Two different polyketide genes are required for synthesis of zearalenone in Gibberella zeae. Molecular Microbiology, 2005, 58(4):1102-1113.
[13] Erik L, Karen R B, Sonja S K. Real-time quantitative expression studies of zearalenone biosynthetic gene cluster in Fusarium graminearum. Mycology, 2009, 99(2):176-184.
[14] Erik L, Klemsdal S S, Bone K R, et al. The PKS4 gene of Fusarium graminearum is essential for zearalenone production. Applied and Environmental Microbiology, 2006, 72(6):3924-3932.
[15] Poppenberger B, Berthiller F, Bachmann H, et al. Heterologous expression of Arabidopsis UDP-glucosyltransferase in Saccharomyces cerevisiae for production of zearalenone-4-O-glucoside. Applied and Environmental Microbiology, 2006, 76(6):4404-4410.
[16] Bswald C, Engelhardt G, Vogel H, et al. Metabolism of the Fusarium mycotoxin zearalenone and deoxynivalenol by yeast strains of technological relevance. Nat Toxins, 1995, 3:138-144.
[17] Kiessling K H, Pettersson H, Sandholm K, et al. Metabolism of aflatoxin, ochratoxin, zearalenone, and three trichothecenes by intact rumen fluid, rumen protozoa, and rumen bacteria. Applied and Environmental Microbiology, 1984, 47:1070-1073.
[18] Shier W T, Shier A C, Xie W, et al. Structure-activity relationships of human estrogenic activity in zearalenone mycotoxins. Toxicon, 2001, 39:1435-1438.
[19] Takahashi-Ando N, Kimura M, Kakeya H, et al. A novel lactonohydrolase responsible for the detoxification of zearalenone: enzyme purification and gene cloning. Biochem. J, 2002, 385:1-6.
[20] Kakeya H, Takahashi-Ando N, Kimura M, et al. Biotransformation of the mycotoxin, zearalenone, to a non-estrogenic compound by a fungal strain of clonostachys sp. Biosci Biotechnol Biochem, 2002, 66(12):2723-2726.
[21] Karlovsky P. Bioloogical detoxification of fungal toxins and its use in plant breeding, feed and food production. Nat Toxins, 1999, 7:1-23.
[22] Higa A, Kimura M, Mimori K, et al. Expression in cereal plants of genes that inactivate Fusarium mycotoxin Biosci Biotechnol Biochem, 2003, 67(4):914-918.
[23] Takahashi-Ando N, Yamaguchi I, Kimura M, et al. Efficient detoxification of zearalenone, the mycotoxin of cereal pathogen by transgenic yeasts through the expression of the synthetic lactonohydrolase gene. Appl Microbiol Biotechnol, 2005, 67:838-844.
[24] Higa-Nishiyama A, Takahashi-Ando N, Shimizu T, et al. A model transgenic cereal plant with detoxification activity for the estrogenic mycotoxin zearalenone. Transgenic Research, 2005, 14:713-717.
[25] Igawa T, Takahashi-Ando N, Ochiai N, et al. Reduced contamination by the Fusarium mycotoxin zearalenone in maize kernels through genetic modification with a detoxification gene. Applied and Environmental Microbiology, 2007, 73(5):1622-1629.
[26] Xiong K, Cheng B, Hu W,et al. Research progress on zearalenone degradation. Journal of the Chinese Cereals and Oils Association, 2010, 25(1):138-142.

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