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中国生物工程杂志

China Biotechnology
China Biotechnology  2011, Vol. 31 Issue (01): 81-85    DOI:
    
Progress in the Study of Yeast Gal4 Transcription Factor
ZHU Kai-chuan, ZHANG Jian-hua, LIU Shi-de
College of Life Sciences, Shenzhen University, Shenzhen 518060, China
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Abstract  

The key step of cellular stress response is transcriptional activation of stress response gene including that transcription factors interact with cis-acting element. Gal4 protein is an evolutionary conserved transcription factor in the process of galactose metabolism. N-terminal DNA binding domain of yeast Gal4 protein binds to the Upstream Activating Sequence and C-terminal activation domain interacts with general transcriptional factors, recruit RNA polymerase Ⅱ to TATA-box. This process is regulated not only by regulating factors Gal80 and Gal3, but also relies on Gal4 dimerization.The role of the yeast Gal4 plays on the transcriptional activation of galactose metabolism genes is illustrated.



Key wordsGal4      Gal80      Gal3      UAS      Transcriptional activation     
Received: 12 August 2010      Published: 25 January 2011
ZTFLH:  Q344+.13  
Cite this article:

ZHU Kai-chuan, ZHANG Jian-hua, LIU Shi-de. Progress in the Study of Yeast Gal4 Transcription Factor. China Biotechnology, 2011, 31(01): 81-85.

URL:

https://manu60.magtech.com.cn/biotech/     OR     https://manu60.magtech.com.cn/biotech/Y2011/V31/I01/81


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