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| D-amino Acid Oxidase:Update and Review |
| GUO Jiao-jie1,2, XUE Yong-chang1, XU Shu-jing2, ZHANG Cai-feng2, HE Guang-zheng2, JU Jian-song2 |
1. College of Bioengineering, Dalian Polytechnic University, Dalian 116034,China;
2. College of Life Science, Hebei Normal Universit, Shijiazhuang 050016,China |
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Abstract D-amino acid oxidase (EC 1.4.3.3, DAAO) is a FADdependent enzyme that plays an important role in metabolism of endogenous D-amino acids in living cells. The D-amino acid oxidase (DAAO) catalyzes oxidative deamination of D-amino acids yielding hydrogen peroxide, ammonium and the corresponding αketo acids. The recent data about this enzyme was summarized, including its physiological role and practical applications, optimization of expression, and the characteristics of some singlepoint mutant enzyme which designed by a rational approach.
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Received: 06 August 2010
Published: 19 November 2010
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Corresponding Authors:
Jian-Song JU
E-mail: jujiansong@126.com
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