[1] Papageorgiou V P,Assimopoulou A N,Samanidou V F, et al. Recent advances in chemistry,biology and biotechnology of alkannins and shikonins. Current Organic Chemistry, 2006, 10:21232142.
[2] 中华人民共和国药典.北京: 中国医药科技出版社, 2010,320. The People's Republic of China Pharmacopoeia.Beijing: China Medical Science Press,2010,320.
[3] 黄志纾, 张敏, 马林, 等. 紫草的化学成分及其药理活性研究概况. 天然产物研究与开发, 2000, 12(01):7281. Huang Z S, Zhang M, Ma L, et al. Natural Product Research and Development, 2000, 12(01):72-81.
[4] 王雪宝, 王英丽, 张阳, 等. 新疆紫草素抗肝癌的研究. 中国误诊学杂志, 2007, 7(16):3727-3728. Wang X B, Wang Y L, Zhang Y, et al. Chinese Journal of Misdiagnostics, 2007, 7(16):3727-3728.
[5] 王英丽, 张阳, 刘力华. 紫草素诱导生殖系肿瘤细胞凋亡的研究. 中国妇幼保健, 2007, 22(25):3585-3587. Wang Y L, Zhang Y, Liu L H. Maternal and Child Health Care of China, 2007, 22(25):3585-3587.
[6] 陈丽梅, 李超民, 关键虹, 等. 紫草素诱导人白血病细胞K562的凋亡. 现代肿瘤医学, 2009, 17(2):209-211. Chen L M, Li C M, Guan J H, et al. Modernoncology, 2009, 17(2):209-211.
[7] 邵振俊, 伍怡颖, 郑小卫, 等. 甲基丙烯酰紫草素的抗肿瘤作用及其机制的研究. 华西药学杂志, 2009, 24(3):24l-243. Shao Z J, Wu Y Y, Zheng X W, et al. West China Journal of Pharmaceutical Sciences, 2009, 24(3): 24l-243.
[8] Zeng Y, Liu G, Zhou L M. Inhibitory effect of acetylshikonin on human gastric carcinoma cell line SGC-7901 in vitro and in vivo. World J Gastroenterol, 2009, 15(15):1816-1820.
[9] Takahiro I, Ikuyo S. Protection of human keratinocytes from UVBinduced inflammation using root extract of Lithospermum erythrorhizon. Biol Pharm Bull, 2007, 30(5):928-934.
[10] Kyong N N, Son M S, Park J H, et al. Shikonins attenuate microglial inflammatory responses by inhibition of ERK, Akt, and NF-kB: neuroprotective implications. Neuropharmacology, 2008, 55:819-825.
[11] Cheng Y W, Chang C Y, Lin K L, et al. Shikonin derivatives inhibited LPSinduced NOS in RAW264.7cells via downregulation of MAPK/NFkappa B signaling. Journal of Ethnopharmacology, 2008, 120:264-271.
[12] Sojin A, Yong D P, Young K P, et al. Human ACAT inhibitory effects of shikonin derivatives from Lithospermum erythrorhizon. Bioorganic & Medicinal Chemistry Letters, 2007, 17:1112-1116.
[13] Kiyomi N, Kyoko Y, Tomo S, et al. A naphthoquinone derivative, shikonin, has Insulin-like actions by inhibiting both phosphatase and tensin homolog deleted on chromosome 10 and tyrosine phosphatases. Mol Pharmacol, 2006, 70:1143-1149.
[14] 葛锋, 王晓东, 王玉春. 药用紫草的研究进展. 中草药, 2003, 34(9):附6附10. Ge F, Wang X D, Wang Y C. Chinese Herbal Medicine, 2003, 34(9):Appendix 6Appendix 10.
[15] 刘志, 吴树敬, 杨永华. 紫草宁形成相关的基因克隆及其代谢工程. 中国生物工程杂志, 2004, 24 (4):26-29. Liu Z, Wu S J, Ynag Y H. China Biotechnology, 2004, 24(4):26-29.
[16] Mizukami M,Konoshima M,Tabata M.Variation in pigment production in Lithospermum erythrorhizon callus cultures.Phytochemistry,1978,17:95-97.
[17] 张华, 曹日强, 杨永华. γ射线对滇紫草细胞产生色素的影响. 植物资源与环境, 1999, 8(1):42-45. Zhang H, Cao R Q, Yang Y H. Journal of Plant Resources and Environment, 1999, 8(1):42-45.
[18] 祁建军, 宋经元, 雷和田, 等. 根癌农杆菌转化紫草的研究. 云南植物研究, 2002, 24(5):656-658. Qi J J, Song J Y, Lei H T. et al. Acta Botanica Yunnanica, 2002, 24(5):656-658.
[19] 陈永芳, 芦韦华, 王 芳, 等. 新疆紫草毛状根的诱导及培养. 西北植物学报, 2008, 28(12):2423-2428. Chen Y F, Lu W H, Wang F, et al. Acta Botanica BorealeOccidentalia Sinica, 2008, 28(12):24232428.
[20] 严海燕, 曹日强. 紫草愈伤组织培养中紫草素形成的影响因素. 华北农学报, 2002, 17(2):116-120. Yan H Y,Cao R C. Acta Agriculturae BorealiSinica, 2002, 17(2):116-120.
[21] 葛锋.新疆紫草细胞和组织培养的过程调控和繁育研究.北京:中国科学院过程工程研究所,2006. Ge F.Process Regulation and Microprogation in Arnebia euchroma Cell and Tissue Culture.Beijing:Institute of Process Engineering, Chinese Academy of Sciences,2006.
[22] 黄平. 水杨酸和IAA, BAP在滇紫草细胞生长和紫草宁合成中的互作及其作用机制的研究. 南京: 南京大学, 2003. Huang P. Interaction Between Exogenous Salicylic Acid,IAA and BAP on Eprowth and Shikonin Formation and its Biochemical Mechanism in Cultured Onosma paniculatum Cells.Nanjing:Nanjing University, 2003.
[23] Yang Y H,Huang J,Ding J. Interaction between exogenous brassinolide, IAA and BAP in secondary metabolism of cultured Onosma paniculatum cells. Plant Growth Regulation, 2003, 39: 253-261.
[24] Ge F, Wang X D,Zhao B, et al. Effects of rare earth elements on the growth of Arnebia euchroma cells and the biosynthesis of shikonin. Plant Growth Regulation, 2006, 48:283-290.
[25] Touno K, Tamaoka J, Ohashi Y, et al. Ethylene induced shikonin biosynthesis in shoot culture of Lithospermum erythrorhizon. Plant Physiology and Biochemistry, 2005, 43:101-105.
[26] Yazaki K, Takeda K, Tabata M. Effects of Methyl Jasmonate on Shikonin and Dihydroechinofuran Production in Lithospermum Cell Cultures. Plant and Cell Physiology, 1997, 38(7): 776-782.
[27] 陈陆. 多胺对滇紫草培养细胞紫草素形成的影响研究. 南京: 南京大学, 2002. Chen L.Eoffect of Polyamime Onshikon in Production in Cultured Pankulatum onosma Cells.Nanjing:Nanjing University, 2002.
[28] 葛锋, 陈朝银, 王晓东, 等. 超声波对新疆紫草悬浮培养细胞生长和紫草素合成的影响. 过 程 工 程 学 报, 2008, 8(1):115-119. Ge F, Chen C Y, Wang X D, et al. The Chinese Journal of Process Engineering, 2008, 8(1):115-119.
[29] Chung B Y, Lee Y B, Baek M H, et al. Effects of lowdose gammairradiation on production of shikonin derivatives in callus cultures of Lithospermum erythrorhizon S. Radiation Physics and Chemistry, 2006, 75:1018-1023.
[30] Wu S J, Qi J L, Zhang W J, et al. Nitric oxide regulates shikonin formation in suspensioncultured Onosma paniculatum Cells. Plant and Cell Physiology, 2009, 50(1):118-128.
[31] Yazaki K, Matsuoka H, Shimomura K,et al. A Novel DarkInducible Protein, LeDI-2, and ItsInvolvement in RootSpecific Secondary Metabolism in Lithospermum erythrorhizon. Plant Physiology, 2001, 125:1831-1841.
[32] Qi J L, Zhang W J, Hu S,et al. Expression analysis of lightregulated genes isolated from a full-lengthenriched cDNA library of Onosma paniculatum cell cultures. Journal of Plant Physiology, 2008, 165(14):1474-1482.
[33] Boehm R, Sommer S, Li S M, et al. Genetic engineering on shikonin biosynthesis:expression of the bacterial ubiA gene in Lithospermum erythrorhizon. Plant and Cell Physiology, 2000, 41(8):911-919.
[34] Khle A, Sommer S, Yazaki K, et al. High level expression of chorismate pyruvate-lyase (UbiC) and HMG-CoA reductase in hairy root cultures of Lithospermum erythrorhizon. Plant and Cell Physiology, 2002, 43(8):894-902.
[35] Matsuno M, Nagatsu A, Ogihara Y. CYP98A6 from Lithospermum erythrorhizon encodes 4coumaroyl-4hydroxyphenyllactic acid 3hydroxylase involved in rosmarinic acid biosynthesis. FEBS Lett., 2002, 514:219-224.
[36] Yazaki K, Kunihisa M, Fujisaki T, et al. Geranyl diphosphate: 4hydroxy benzoate geranyltransferase from Lithospermum erythrorhizon. Journal of Biological Chemistry, 2002, 277(8):6240-6246.
[37] 薛莲, 孟琴, 吕德伟. 紫草细胞的双液相培养研究. 化学反应工程与工艺, 2000, 16(1):40-44. Xue L, Meng Q, Lv D W. Chemical Reaction Engineering and Technology, 2000, 16(1):40-44.
[38] Ge F, Yuan X F, Wang X D, et al. Cell growth and shikonin production of Arnebia euchroma in a periodically submerged airlift bioreactor. Biotechnology Letters, 2006, 28:525-529.
[39] Noula E, Samanidou V F, Assimopoulou A N, et al. Solidphase extraction for purification of alkannin/shikonin samples and isolation of monomeric and dimeric fractions. Anal Bioanal Chem, 2010, 397:2221-2232.
[40] Papageorgiou V P, Assimopoulou A N, Samanidou V F, et al. Analytical methods for the determination of Alkannins and Shikonins. Current Organic Chemistry, 2006,10:583-622.
[41] Zare K, Khosrowshahli M, Nazemiyeh H, et al. Callus culture of Echium italicum L. towards production of a shikonin derivative. Nat Prod Res, 2010, 13:1-8. |