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Advances in Applications of Elastin-like Polypeptides in Biomedical Materials |
HUANG Kai-zong,WANG Wen-yan,ZHANG Guang-ya |
Department of Bioengineering and Biotechnology,Huaqiao University,Xiamen 362021,China |
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Abstract Elastin-like polypeptides(ELPs) were a family of artificial, genetically encodable polypeptidesthey are primarily composed of the repeating pentapeptide sequence GVGXP. Due to their reversible phase transition characteristics, ultra-high production, excellent biocompatibility and biodegradation, ELPs had an intensive potential in new biomedical materials. Describes principle of ELPs’ phase transition, and its applications in biomedical materials,especially gives emphasis to introduce the applications of tissue engineering, targeting tumor and constructing of drug carrier particle.
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Received: 26 November 2009
Published: 25 May 2010
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[1] Urry D W,Luan C H,Parker T M ,Gowda D C,et al.Temperature of polypeptide inverse temperature transition depends on mean residue hydrophobicity.Journal of the American Chemical Society,1991,113(11):43464348.
[2] Urry D W.Physical chemistry of biological free energy transduction as demonstrated by elastic proteinbased polymers.Journal of Physical Chemistry B,1997,101(51):1100711028.
[3] Long M M,Urry D W,Cox B A,et al.Coacervation of repeat sequences of elastin.Biophys,1975,15:A71(Abstr).
[4] Urry D W.Molecular mechanisms of elastin coacervation and coacervate calcification.Journal of the American Chemical Society,1976,61:205212.
[5] Urry D W.Molekulare Maschinen: Wie Bewegung und andere Funktionen lebender Organismen aus reversiblen chemischen ?nderungen entstehen.Angewandte Chemie,2006,105:859883.
[6] Urry D W. Biomolekulare maschinen aus elastischen polymeren.Spektrum der Wissenschaft,1995,4:4447.
[7] Dybal J,Schmidt P,Kurková D,et al.Temperature induced conformational transitions of elastinlike polypentapeptides studied by Raman and NMR spectroscopy.Spectroscopy,2002,16:251255.
[8] Gross P C,Possartb W,Zeppezauer M.An alternative structure model for the polypentapeptide in elastin.Journal of Biosciences,2003,58(1112):873878 .
[9] Serrano V,Liu W,Franzen S.An infrared spectroscopic study of the conformational transition of elastinlike polypeptides.Biophysical Journal,2007,93:24292435.
[10] Urry D W,Parker T M.Mechanics of elastin: molecular mechanism of biological elasticity and its relationship to contraction.Journal of Muscle Research and Cell Motility,2002,23:543559.
[11] Urry D W,Hugel T,Seitz M,et al.Elastin: a representative ideal protein elastomer.The Royal Society,2002,357:169184.
[12] RodríguezCabello J C,Reguera J,Alonso M,et al.Endothermic and exothermic components of an inverse temperature transition for hydrophobic association by TMDSC.Chemical Physics Letters,2004,388:127131.
[13] Chow D,Nunalee M L,Lim D W.Peptidebased biopolymers in biomedicine and biotechnology.Materials Science and Engineering R,2008,62:125155.
[14] Meyer D E,Chilkoti A.Genetically encoded synthesis of proteinbased polymers with precisely specified molecular weight and sequence by recursive directional ligation:examples from the elastinlike polypeptide system.Biomacromolecules,2002,3:357367.
[15] Chow D C,Dreher M R,CarlsonK T,et al.Ultrahigh expression of a thermally responsive recombinant fusion protein in E.coli.Biotechnol Prog,2006,22(3):638646.
[16] Langer R,Vacanti J P.Tissue engineering.Science,1993,260:920927.
[17] Urry D W,Xu T C,Parker T M.Elastic proteinbased polymers in soft tissue augmentation and generation.Journal of Biomaterials SciencePolymer Edition,1998,9:10151048.
[18] Betre H,Setton L A,Meyer D E,et al.Characterization of a genetically engineered elastinlike polypeptide for cartilaginous tissue repair.Biomacromolecules,2002,3 (5):910916.
[19] Betre H; Ong S R; Guilak F,et al.Chondrocytic differentiation of human adiposederived adult stem cells in elastinlike polypeptide.Biomaterials,2006,27:9199.
[20] Lim D W,Nettles D L,Setton L A,et al.In situ crosslinking of elastinlike polypeptide block copolymers for tissue repair.Biomacromolecules,2008,9:222230.
[21] Martín L,Alonso M,Girotti A,et al.Synthesis and characterization of macroporous thermosensitive hydrogels from recombinant elastinlike polymers,Biomacromolecules,2009,10:30153022.
[22] MartínezOsorio H,JuárezCampo M,Diebold Y,et al.Genetically engineered elastinlike polymer as a substratum to culture cells from the ocular surface.Current Eye Research,2009,34(1):4856.
[23] Annabi N,Mithieux S M,Boughton E A,et al.Synthesis of highly porous crosslinked elastin hydrogels and their interaction with fibroblasts in vitro.Biomaterials,2009,3:18.
[24] Kyle S,Aggeli A,Ingham E,et al.Production of selfassembling biomaterials for tissue engineering.Trends in Biotechnology,2009,27(7):423433.
[25] Hart D S,Gehrke S H.Thermally associating polypeptides designed for drug delivery produced by genetically engineered cells.Pharmaceutical Sciences,2007,96:484516.
[26] Meyer D E,Kong G A,Dewhirst M W,et al.Targeting a genetically engineered elastinlike polypeptide to solid tumors by local hyperthermia.Cancer Research,2001,61(4):15481554.
[27] Liu W,Dreher M R,Furgeson D Y,et al.Tumor accumulation degradation and pharmacokinetics of elastinlike polypeptides in nude mice.Journal of Controlled Release,2006,116 (2):170178.
[28] Dreher M R,Liu W,Michelich C R,et al.Thermal cycling enhances the accumulation of a temperaturesensitive biopolymer in solid tumors.Cancer Research.2007,67(9):44184424.
[29] Ryu B Y,Sohn J S,Hess M,et al.Synthesis and anticancer efficacy of rapid hydrolysed watersoluble paclitaxel prodrugs.Biomaterials Science,2008,19 (3):311324.
[30] Yeung T K,Hopewell J W,Simmonds R H,et al.Reduced cardiotoxicity of doxorubicin given in the form of N(2hydroxypropyl)methacrylamide conjugates and experimental study in the rat.Cancer Chemotherapy and Pharmacology,1991,29(2):105111.
[31] Duncan R,Coatsworth J K,Burtles S.Preclinical toxicology of a novel polymeric antitumour agent:HPMA copolymerdoxorubicin (PK1) .Human and Experimental Toxicology,1998,17 (2):93104.
[32] Betre H,Liu W,Zalutsky M R,et al.A thermally responsive biopolymer for intraarticular drug delivery.Journal of Controlled Release,2006,115 (2):175182.
[33] Shamji M F,Whitlatch L,Friedman A H,et al.An injectable and in situgelling biopolymer for sustained drug release following perineural administration.Spine,2008,33(7):748754.
[34] Fujita Y,Mie M,Kobatake E.Construction of nanoscale protein particle using temperaturesensitive elastinlike peptide and polyaspartic acid chain.Biomaterials,2009,30:34503457.
[35] Osborne J L,Farmer R,Woodhouse K A.Selfassembled elastinlike polypeptide particles.Acta Biomaterialia.2008,4:4957.
[36] Wu Y Q,MacKay J A,McDaniel J R,et al.Fabrication of elastinLike polypeptide nanoparticles for drug delivery by electrospraying.Biomacromolecules,2009,10:19–24.
[37] MacKay J A,Chen M,McDaniel J R,et al.Selfassembling chimeric polypeptide–doxorubicin conjugate nanoparticles that abolish tumours after a single injection.Nature Materials.2009,8:993999. |
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