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Genetic Engineering Vaccine of Toxoplasma Gondii |
XU An-jian, GU Jun-chao |
Beijing Tropical Disease Institute,Beijing Friendship Hospital, Beijing 100050,China |
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Abstract The Toxoplasma gondii vaccine is the best way to prevent Toxoplasma gondii infection. The improvement of the biological techology promots the study of Toxoplasma gondii vaccine. The newest study progresses of Toxoplasma gondii genetic engineering vaccine, which is summarized on the basis of the current study results, is respected to provide new aspects of the Toxoplasma gondii vaccine study for the researches.
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Received: 03 August 2009
Published: 07 December 2009
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[1] |
MH el Kouni. Adenosine metabolism in Toxoplasma gondii: potential targets for chemotherapy. Curr Pharm Des, 2007,13(6): 581~597
|
|
|
[2] |
Jongert E, Roberts C W, Gargano N, et al. Vaccines against Toxoplasma gondii: challenges and opportunities. Mem Inst Oswaldo Cruz, 2009, 104(2): 252~266
|
|
|
[3] |
Bout D T, Mevelec M N, VelgeRoussel F, et al. Prospects for a human Toxoplasma vaccine. Curr Drug Targets Immune Endocr Metabol Disord, 2002, 2(3): 227~234
|
|
|
[4] |
Kasper L H, Bradley M S, Pfefferkorn E R, et al. Identification of stagespecific sporozoite antigens of Toxoplasma gondii by monoclonal antibodies. J Immunol, 1984, 132: 443~449
|
|
|
[5] |
Partanen J, Braekeleer D, Diet R, et al. Complete protection against lethal Toxoplasma gondii infection in mice immunized with a plasmid encoding the SAG1 gene. J Clin Microbiol, 1984,20(1): 133~135
|
|
|
[6] |
司进,汤俊明,赵松,等.刚地弓形虫RH株主要表面抗原1的原核表达和纯化及免疫反应性检测.中华检测医学杂志,2004,27(2):107~109 Si J, Tang J M, Zhao S, et al. Chinese Journal of Laboratory Medicine, 2004,27(2):107~109
|
|
|
[7] |
Kim K, Bulow R, Kampmeier J, et al. Conformationally appropriate expression of the Toxoplasma gondii SAG1(P30) in CHO cells. Infect Immun, 1994,62: 203~209
|
|
|
[8] |
Liu Q, Gao S, Jiang L, Shang L, et al. A recombinant pseudorabies virus expressing TgSAG1 protects against challenge with the virulent Toxoplasma gondii RH strain and pseudorabies in BALB/c mice. Microbes Infect, 2008, 10(12,13): 1355~1362
|
|
|
[9] |
Aline F, Bout D, Amigorena S, et al. Toxoplasma gondii antigenpulseddendritic cellderived exosomes induce a protective immune response againsr T. gondii infection. Infect Immun, 2004, 72(7): 4127~4137
|
|
|
[10] |
Garcia J L, Navarro I T, Biazzono L, et al. Protective activity against oocyst shedding in cats vaccinated with crude rhoptry proteins of the Toxoplasma gondii by the intranasal route. Vet Parasitol, 2007, 145(3,4): 197~206
|
|
|
[11] |
Leyva R, Herion P, Saacedra R. Genetic immunization with plasmid DNA coding for the ROP2 protein of Toxoplasma gondii. Parasitol Res, 2001, 87(1): 70~79
|
|
|
[12] |
Tait E D, Hunter C A. Advances in understanding immunity to Toxoplasma gondii. Mem Inst Oswaldo Cruz, 2009, 104(2): 201~210
|
|
|
[13] |
杨婷婷,何深一,蒋华,等.弓形虫主要表面抗原P30单价及复合基因疫苗的构建.中国寄生虫学与寄生虫病杂志,2005,23(1):14~17 Yang T T, He S Y, Jiang H, et al. Chinese Journal of Parasitology and Parasitic Diseases, 2005,23(1):14~17
|
|
|
[14] |
Igarashi M, Kano F, Tamekuni K, et al. Toxoplasma gondii: evaluation of an intranasal vaccine using recombinant proteins against brain cyst formation in BALB/c mice. Exp Parasitol, 2008, 118(3): 386~392
|
|
|
[15] |
张佃波,周林涛,王海防,等.刚地弓形虫ROPP30复合重组蛋白疫苗对BLAB/c小鼠免疫保护性的研究.中国病原生物学杂志,2008,3(10): 763~767 Zhang X B, Zhou L T, Wang H F, et al. Journal of Parasitic Biology, 2008,3(10): 763~767
|
|
|
[16] |
Debard N, BuzoniGatel D, Bout D. Intranasal immunization with SAG1 protein of Toxoplasma gondii in association with cholera toxin dramatically reduces development of cerebal cysts after oral infection. Infect Immun, 1996, 64(6): 2158~2166
|
|
|
[17] |
MartinezGomez F, GarciaGonzalez L F, MondragonFlores R, et al. Protection against Toxoplasma gondii brain cyst formation in mice immunized with Toxoplasma gondii cytoskeleton proteins and Lactobacillus casei as adjuvant. Vet Parasitol, 2009, 160(3,4): 311~315
|
|
|
[18] |
Hedhli D, DimierPoisson I, Judge J W, et al. Protective immunity against Toxoplasma challenge in mice by coadministration of T. gondii antigens and Eimeria profilinlike protein as an adjuvant. Vaccine, 2009, 27(16): 2274~2281
|
|
|
[19] |
MoralesSainz L, EscobarRamirez A, CruzTorres V, et al. The polypeptides COX2A and COX2B are essential components of the mitochondrial cytochrome coxidase of Toxoplasma gondii. Biochim Biophys Acta, 2008, 1777(2): 202~210
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