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中国生物工程杂志

China Biotechnology
China Biotechnology  2009, Vol. 29 Issue (08): 124-128    DOI:
    
Looming of the Era for the Induced Pluripotent Stem Cells by Direct Nuclear Reprogram
 MAO Yi, SUN Ji
West China Second University Hospital Sichuan University, Chengdu610041,China
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Abstract  

Induced pluripotent stem cells (iPS) are derived from the differentiated somatic cells that regain the differentiation capabilities by the direct nuclear reprogramming with the exogenous factors. The methods for iPS induction evolved from transcription factors to RNA binding proteins, small molecules, and extracellular signals with the efforts in improving biosafty. The cellular and epigenetic characterization for iPS generation is a progressive and timedependent process, which is tightly associated with the cellular differentiation status. However, epigenetics of iPS is not same as the embryonic stem cells. In combination with gene therapy and cellular transplantation therapy, the achievements of iPS had been applied in animal disease model treatment.



Key wordsinduced pluripotent stem cells;direct nuclear reprogram;transcriptional regulation;cell therapy     
Received: 07 November 2008      Published: 28 July 2009
ZTFLH:  Q291  
Cite this article:

MAO Yi, SUN Ji. Looming of the Era for the Induced Pluripotent Stem Cells by Direct Nuclear Reprogram. China Biotechnology, 2009, 29(08): 124-128.

URL:

https://manu60.magtech.com.cn/biotech/     OR     https://manu60.magtech.com.cn/biotech/Y2009/V29/I08/124

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