Progress and insight of miRNA on hepatocellular carcinoma

China Biotechnology

2008, Vol. 28

Issue (12): 94-101 DOI:

Progress and insight of miRNA on hepatocellular carcinoma

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Abstract

MicroRNAs (miRNAs) are endogenous non-coding RNAs, about 20 nucleotides in length. They play a pivotal role in the regulation of genes involved in diverse biology processes such as cell development, proliferation, differentiation and apoptosis by the translation repression or mRNA degradation. Recent evidence has suggested that miRNA alterations are involved in the initiation and progression of various human cancer including hepatocellular carcinoma (HCC), and miRNA-expression profiling of HCC has identified signatures associated with diagnosis, staging, progression and prognosis．As a novel molecular target, miRNAs holds great promise in diagnosis and biotherapy of HCC．

Key words： MicroRNAs Hepatocellular carcinoma Diagnosis Biotherapy

Received: 07 July 2008 Published: 20 April 2009

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	CU Peng
	GAO Chun-Fang

Cite this article:

. Progress and insight of miRNA on hepatocellular carcinoma. China Biotechnology, 2008, 28(12): 94-101.

URL:

https://manu60.magtech.com.cn/biotech/ OR https://manu60.magtech.com.cn/biotech/Y2008/V28/I12/94

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