中国生物工程杂志

Effect of Microbial Transglutaminase from Streptoverticillium SG215 on cutaneous wound healing in rats was evaluated using excision wound model. The wounds were visually observed, photographically documented and the wound area was measured at 5, 10, 15, 20th days. The volume of wound was measured by water injection method, the contents of protein, hydroxyproline (Hyp), hexuranic, hexosamines in the granulation tissues and regeneration of granulation tissues were investigated. The closure time and volume of the skin wounds in the experimental groups significantly decreased when compared to that in the control group (P<0.05). Wound contraction, dry(or wet) weight of granulation tissues and content of protein, Hydroxyproline, Hexuranic, Hexosamines in the wound tissues in the experimental groups were higher than that in the control group (P<0.05).These results clearly substantiate the beneficial effects of microbial transglutaminase in wound healing.