Abstract Rare sugars were defined as monosaccharides and their derivatives that rarely exist in nature. They played an important role in food, health, medicine and etc.. A strategy for bioproduction of rare sugars, namely Izumoring, was reviewed in this paper. By the Izumoring method, all monosaccharides and polyols could be linked using enzymatic reaction with D-tagatose 3-epimerase, aldose isomerases and polyol dehydrogenases. According to this strategy, the Izumoring for hexoses, pentoses and tetroses were designed respectively, and the bioproduction routes of various rare sugars, using microbial and enzymatic reactions, could be obtained.
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