Abstract As a group of important transcription factors, NF-κB are composed of members of Rel/NF-κB family. For most kinds of cells, NF-κB with IκB (inhibition protein) binding normally is existed in inactived form in cytoplasm. With efficient stimulus, NF-κB can be activated through signal transduction pathways, resulting in the escape form from IκB binding, and should be transported into nuclear where is the proper locale for it to exert its transcriptional regulation function on a great deal of genes. However, in abnormal cases, there will be mistaken expression and activation of NF-κB, which has been testified to be close relationship with many disease genesis, including inflammation and cancer, and so on. However, in the other cases, activation of NF-κB could repress disease development. To inhibit the abnormal activity and function of NF-κB has been shown to be an effective strategy for therapy of relative diseases. With relative research development, NF-κB should have bright prospect as a target for novel drug design and relative disease therapy.
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