Please wait a minute...

中国生物工程杂志

China Biotechnology
China Biotechnology  2007, Vol. 27 Issue (11): 86-91    DOI:
    
Progress, applications and prospects of epitope vaccine
Download: HTML   PDF(420KB) HTML
Export: BibTeX | EndNote (RIS)      

Abstract  

Epitope vaccine is one of the emerging vaccine techniques developing in past decade years. Particularly the advantages of this vaccine on preventing and therapy illness, as cancer and virus, are espacially outstanding. In this article, the most importent elements about the vaccine, namely T/B-epitopes obtainment and identification, vehicles for epitope and vaccine construction, are reviewed. In addition, applications of the vaccine technique in some refractory diseases, such as cancer, virus and pathogen infection, are depicted.



Key wordsEpitope      T-epitope      B-epitoe      Epitope vaccine     
Received: 21 August 2007      Published: 25 November 2007
Cite this article:

. Progress, applications and prospects of epitope vaccine. China Biotechnology, 2007, 27(11): 86-91.

URL:

https://manu60.magtech.com.cn/biotech/     OR     https://manu60.magtech.com.cn/biotech/Y2007/V27/I11/86

[1] GUO Le,WANG Shu-e,HE Meng,ZHANG Fan,LIU Hong-peng,LIU Kun-mei. Expression and Immunological Properties of Multivalent Epitope Vaccine CWAE Against Helicobacter pylori[J]. China Biotechnology, 2019, 39(12): 1-8.
[2] SUN Wen-jia, YAO Yu-feng, YANG Xu, HUANG Wei-wei, LIU Cun-bao, LONG Qiong, CHU Xiao-jie, MA Yan-bing. Presentation of HPV 16L1 Peptide-based HBcAg Virus-like Particle and Induction of Specific Antibody[J]. China Biotechnology, 2017, 37(3): 58-64.
[3] LI Chao, LIU Bo, TAO Yu-fen, LI Xin-tong, LIU Jian-sheng, LIU Hong-qi. Expression of Chimeric Protein of Norovirus P Domain and Neutralizing Epitopes of EV71 in Prokaryotic Escherichia coli[J]. China Biotechnology, 2017, 37(1): 1-6.
[4] WANG Jing, XIA Wen-yue, PAN Xiao-xia, ZHAO Bing-xin, TENG Yu-mei, LI Chuan-yin, YANG Xiao-zhou, WEN Yu-ling, CHEN Yuan-ding. Immunological Activity of a Chimeric Protein Carrying an Epitope of Type 2 Poliovirus on the VP6 of Rotavirus as a Vector[J]. China Biotechnology, 2016, 36(8): 1-8.
[5] XUE Ling, LIU Jiang-ning, ZHANG Yao, ZHANG Chun, WANG Qi, QIN Chuan, LIU Yong-dong, SU Zhi-guo. Affinity Purification of Enterovirus 71 Fused Multi-Epitope Protein Antigen and Assembling It as Virus-like Particles in Vitro[J]. China Biotechnology, 2016, 36(7): 34-40.
[6] XIA Wen-yue, WANG Jing, ZHAO Bing-xin, PAN Xiao-xia, WEN Yu-ling, CHEN Yuan-ding . Comparative Analysis of Two Rotavirus VP4 Epitopes Inserted on the Same Site of VP6 Vector Protein[J]. China Biotechnology, 2015, 35(8): 9-15.
[7] GUO Le, LIU Kun-mei, QIN Yu-hong, LI Xiao-kang, DUAN Xiang-guo, YANG Hua, XU Guang-xian, XI Tao. Bioinformatics Analysis and Optimized Expression of the Epitope Vaccine rCtUBE[J]. China Biotechnology, 2013, 33(10): 44-50.
[8] LI Pu, SHI Jing, CHENG Fen, LIANG Qin-dong, KUANG Wen-bin, WANG Qin, DONG Jin-yu, TU Zhi-guang. Preparation, Characterization and Application of Monoclonal Antibodies Against Human Y box-binding Protein 1[J]. China Biotechnology, 2012, 32(6): 13-19.
[9] LIU Ying-fu, HUO Jing-rui, FAN Guo-cai, SUN Zhi-xian, WANG Qing-ming. Construction and Verification of a Novel System for B-cell Epitope Display[J]. China Biotechnology, 2012, 32(6): 64-68.
[10] CUI Ming-quan, XU Jie, ZHANG Ting-ting, WANG Tong-kun, SHANG Wei, CHEN Ze-liang, YUAN Jing, DU Xin-ying, WANG Zhou-jia, KE Yue-hua, ZHONG Zhi-jun, YUAN Xi-tong, HUANG Liu-yu, PENG Guang-neng, WANG Yu-fei. Epitope Tagging of the hfq Gene in Brucella melitensis by Suicide Plasmid[J]. China Biotechnology, 2012, 32(11): 75-80.
[11] CUI Ming-quan, XU Jie, ZHANG Ting-ting, WANG Tong-kun, SHANG Wei, CHEN Ze-liang, YUAN Jing, DU Xin-ying, WANG Zhou-jia, KE Yue-hua, ZHONG Zhi-jun, YUAN Xi-tong, HUANG Liu-yu, PENG Guang-neng, WANG Yu-fei. Epitope Tagging of the hfq Gene in Brucella melitensis by Suicide Plasmid[J]. China Biotechnology, 2012, 32(11): 75-80.
[12] FENG Xiao-yan, WANG Yang-chun, LI Ping-chao, TAO Hao-xia, WANG Peng, YUAN Sheng-ling, WANG Ling-chun, WANG Pu, LIU Chun-jie. Surface Display Expression of Helicobacter pylori Ure B Fusion Epitope[J]. China Biotechnology, 2011, 31(8): 35-39.
[13] SHU Lu, LONG Quan-Ke, LIU Hai-Feng, LU Meng-Bei, HU Yuan, DAN You-En, TU Long-Jiang. Construction and Immuno-protection Evaluation of Trivalent-epitope DNA Vaccine pVIVO2-SjFABP/Sj26.SjGAPDH[J]. China Biotechnology, 2010, 30(05): 36-42.
[14] LI Qiu-Xia, TENG Da, TONG De-Wen, YANG Ya-Lin, TIAN Zi-Gang, WANG Jian-Hua. Prokaryotic Expression of Major Epitope Domain of African Swine Fever Virus VP73 Gene[J]. China Biotechnology, 2010, 30(02): 60-65.
[15] . Prediction and Prokaryotic Expression of the Mutual Epitope from all Plasmid-mediatedAmpC β-lactamases[J]. China Biotechnology, 2008, 28(9): 32-38.