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| Research Progress in Protein Corona of Extracellular Vesicles |
WANG Shan,CAO Yulin,WU Di,QU Jiao,YU Yali,LI Qiubai**( ) |
| Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China |
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Abstract Extracellular vesicles are natural nanoparticles with a phospholipid bilayer membrane structure released by cells. They play a vital role in various physiological and pathological processes such as cell signaling, tumor development, immune regulation, and rejuvenation during aging. They have immense potential in the diagnosis and treatment of disease. Previous research has shown that the preparation of extracellular vesicles is prone to protein contamination, which limits their research and translational applications in biomarkers and drug delivery. In recent years, some scholars have introduced the concept of “protein corona” to the field of extracellular vesicles, which is proven to be an important structure for synthetic nanoparticles. They propose that the protein corona is an intrinsic component of the extracellular vesicle and significantly influences its biological functionality. This challenges the traditional view of protein contamination and leads to a paradigm shift in extracellular vesicle research. This review provides an overview of the current state of research on the protein corona on the surface of extracellular vesicles. It covers aspects such as the formation process, chemical composition, biological functions, and identification methods of this protein corona. This review may serve as a reference for the further study of extracellular vesicles and their protein corona.
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Received: 21 August 2023
Published: 03 April 2024
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