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| Research Progress on Bacteria in Anti-tumor Therapy |
SHI Enyu1,WANG Ning1,ZHAO Xiyue2,CHEN Bo1,CAO Mingxin1,LI Changyi1,**( ) |
1 School and Hospital of Stomatology, Tianjin Medical University,Tianjin 300070, China
2 School of Optometry and Ophthalmology, Tianjin Medical University,Tianjin 300070, China |
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Abstract Cancer is a leading cause of death. Although modern medicine has made significant progress in cancer treatment, traditional treatment methods still have limitations due to problems such as cancer heterogeneity, drug resistance, and treatment side effects. With the development of science and technology, bacterial therapy has shown great potential in the field of anti-tumor therapy. Bacteria have the natural ability to target tumors due to their survival characteristics and contain a large number of immune-activating substances, which can modulate the tumor microenvironment and activate the immune system for tumoricidal effect to kill the tumor. Some bacteria can also directly kill tumor cells and inhibit tumor angiogenesis through various pathways. Through in-depth research, scientists have also found that bacteria combined with radiotherapy, chemotherapy, and immunotherapy have gradually become the mainstream strategy of bacterial therapy. In addition, exogenous genes can be inserted into bacteria to perform specific functions according to clinical needs. When combined with various treatment modalities, it is possible to improve their therapeutic effect against tumor, and reduce the toxic side effects. The research progress of bacteria in anti-tumor therapy has been summarized from the aspects of the basic principles, types of bacteria mainly used, optimization strategies, and clinical trials and cases, in order to provide more effective therapeutic strategies for cancer patients by fully exploiting the potential of bacteria.
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Received: 13 July 2023
Published: 03 April 2024
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