Advances in Extraction Processes of Biodegradable Biomaterials PHA

doi:10.13523/j.cb.2306022

China Biotechnology

2023, Vol. 43

Issue (11): 105-115 DOI: 10.13523/j.cb.2306022

Advances in Extraction Processes of Biodegradable Biomaterials PHA

LU Cheng-rong¹,ZHANG Meng-jun^1,^2,^**(

),ZHENG Wei-shuang^1,²,LU Xiao-juan¹,YU Sheng-yang¹,HUANG Yi^1,³

1 Peking University Shenzhen Institute, Shenzhen 518057, China
2 PKU-HKUST Shenzhen-Hongkong Institution, Shenzhen 518057, China
3 College of Environmental Sciences and Engineering, Peking University, Beijing 100871, China

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Abstract

As a class of polymer polyester widely existing in microbial cells, Polyhydroxyalkanoate (PHA) has complete biodegradability and excellent biocompatibility, and is considered to be one of the most environmentally friendly bio-based polymer materials. In recent years, the utilization of synthetic biotechnology in genetically modified PHA-producing bacteria, coupled with the escalating demand for eco-friendly materials such as PHA in social and economic development, has led to significant advancements in PHA fermentation technology. However, the extraction cost has emerged as a pivotal factor impeding the commercial application of PHA. This article comprehensively summarizes the technologies and principles underlying various PHA extraction processes, encompassing physical, chemical and biological methods. Furthermore, it conducts a comparative analysis of the advantages and disadvantages associated with each extraction process, with the aim of providing valuable information and references for further cost reduction and efficiency enhancement in PHA extraction. Building upon the current state of PHA extraction process development, this article also presents prospects for the development of PHA extraction. Presently, PHA extraction processes typically combine multiple extraction methods to overcome the limitations of individual techniques; however, process conditions still necessitate optimization. The application of a novel PHA recovery biological system constructed using synthetic biotechnology holds great promise as the most effective strategy for reducing the cost of PHA extraction in the future.

Key words： Polyhydroxyalkanoate Physical extraction method Chemical extraction method Biological extraction method Synthetic biotechnology

Received: 15 June 2023 Published: 01 December 2023

ZTFLH:

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Corresponding Authors: Meng-jun ZHANG E-mail: zhangmj@ier.org.cn

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	Cheng-rong LU
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	Xiao-juan LU
	Sheng-yang YU
	Yi HUANG

Cite this article:

LU Cheng-rong,ZHANG Meng-jun,ZHENG Wei-shuang,LU Xiao-juan,YU Sheng-yang,HUANG Yi. Advances in Extraction Processes of Biodegradable Biomaterials PHA. China Biotechnology, 2023, 43(11): 105-115.

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https://manu60.magtech.com.cn/biotech/10.13523/j.cb.2306022 OR https://manu60.magtech.com.cn/biotech/Y2023/V43/I11/105

Table 1 Comparison of PHA extraction methods

Table 2 Summary of PHA extracted by different chemical methods

Fig.1 Comparison of PHA extraction with organic solvent and non-organic solvent

Fig.2 Biological extraction of PHA

Fig.3 Extraction of PHA by synthetic biotechnology

Table 3 Extraction process of PHA production companies


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