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Advance in Metabolite-mediated Non-enzymatic Post-translational Modifications |
DONG Yuan-yuan,BAO Qiu-yu,WANG De-xiang,WEN Hong-tao,YANG Xing-chao,WAN Ning**(),YE Hui**() |
Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China |
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Abstract Endogenous small molecules play vital roles in the cell lifespan, such as supplying the energy and substrates for biological processes and mediating cellular communication. Previous studies have shown that some endogenous reactive molecules can non-enzymatically modify proteins via spontaneous chemical reactions, thereby regulating protein structure and functions and participating in various cellular processes. Recently, the rapid development of proteomics technology for capturing non-enzymatically modified target proteins contributes to elucidating the function of the modified target protein. This review focuses on reversible and irreversible non-enzymatic covalent modifications (NECMs) produced by active metabolites, respectively, and introduces the formation mechanism of NECMs and the application of proteomics in the discovery of new post-translational modifications (PTMs) and the elucidation of metabolites-regulated protein functions.
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Received: 18 April 2023
Published: 02 November 2023
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