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| Advances in the Construction and Application of Bone Organoids |
TANG Zi-hui1,ZHONG Chang1,DUAN Yan-li2,MA Rui-yu1,ZHOU Ping1,**( ) |
1 School of Stomatology, Lanzhou University, Lanzhou 730000, China
2 The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China |
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Abstract Bone diseases, such as osteoporosis and osteoarthritis, have become a serious human health hazard, making it imperative to further understand the pathogenesis of related diseases and develop more effective treatments. Due to the limitations of conventional research methods such as two-dimensional cell culture and animal experiments, the organoid technology that emerged in recent years has attracted tremendous attention. As self-organized 3D clusters derived from stem cells, organoids can recapitulate the complex structure and biological function of tissues or organs in vitro. Until now, bone organoids generated from mesenchymal stem cells, pluripotent stem cells and other cell sources have been gradually established, which not only provides an excellent platform for disease modeling, drug screening as well as fundamental research of physiology and pathology, but also raises new hope for repairing bone defects. This review summarizes the construction and main applications of various bone organoid models. The challenges faced by organoid cultivation and future development prospects are also discussed, so as to provide reference for the construction and biomedical application of bone organoids with more perfect structure and functions.
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Received: 03 February 2023
Published: 05 September 2023
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