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Application of Immunoinformatics in Epitope Vaccine Development |
Hong-sheng FENG1,2,Hang JIN1,2,Yong-yu GAO3,Yu-han XIAN1,2,Hai-yang LI1,2,Si-yu YANG1,2,Ai-ming JIA4,**(),Feng-shan GAO1,2,**() |
1 College of Life and Health, Dalian University, Dalian 116622, China 2 The Dalian Gene and Protein Engineering for Drug Screening Key Laboratory, Dalian 116622, China 3 College of Veterinary Medicine, Jilin Agricultural University, Changchun 130118, China 4 The Second Hospital of Dalian Medical University, Dalian 116027, China |
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Abstract Presently, to design epitope vaccines, the research and development process is generally to use computer-aided immunoinformatics tools and related technical methods to analyze acquired or known nucleotide and amino acid sequences to determine and pre-screen out possible dominant epitopes, and then prepare polypeptide vaccines with dominant epitopes through synthetic or genetic engineering techniques. The rapid development of immunoinformatics has been successfully applied to the field of vaccinology, and the immunoinformatics method is the most effective method to develop vaccines based on epitope polypeptide. Immunoinformatics, the general process of immunoinformatics in epitope vaccine design and validation, the immunoinformatics tools involved in the design of epitope vaccines, and the specific application of immunoinformatics in the design of epitope vaccines are reviewed, which will provide reference for reasonable design and development of effective epitope vaccines.
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Received: 15 January 2023
Published: 03 August 2023
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