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Biomimetic Nanomedicine Delivery System Preparation and Disease Therapy Application |
Lin-ying LIU1,**(),Jie SHEN2,Liang CHEN1,Hu-cheng ZHANG1,Xin-ying ZHAO1 |
1 College of Bioengineering, Beijing Polytechnic, Beijing 100176, China 2 State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China |
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Abstract Nanodrug delivery systems are widely used in disease treatment due to their special physical and chemical properties. However, the traditional synthetic nanoparticles cannot cross the natural barrier, and it is difficult to escape immune surveillance, so they are not effective in clinical applications. Biomimetic nanoparticles are obtained by modification of natural materials or by chemical methods imitating the key characteristics of biological structures. They are similar to biologically related structures in chemistry, physics or morphology. Therefore, they exhibit excellent intelligent delivery performance in inert rejection, barrier overcoming and active effects, and can be used for more efficient and safe drug delivery. Biomimetic nano-drug delivery systems are divided into four categories: nano-drug delivery systems designed based on natural biological macromolecules, drug delivery systems related to cells and cell membranes, drug delivery systems of extracellular vesicles such as extracellular secretions, and nano drug delivery systems mimicking biological structures. The design principle of biomimetic nanoparticles used for drug delivery is summarized, the preparation methods of four kinds of biomimetic nanoparticle drug delivery systems are elaborated, the research progress of their application in rare diseases, neurodegenerative diseases, tumors, antiviral vaccine research and development and other targeted therapies is summarized, and the clinical application challenges, potential solutions and future research directions in this field are also discussed.
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Received: 23 December 2022
Published: 03 August 2023
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[1] |
Mano J F, Choi I S, Khademhosseini A. Biomimetic interfaces in biomedical devices. Advanced Healthcare Materials, 2017, 6(15): 1700761.
doi: 10.1002/adhm.v6.15
|
|
|
[2] |
Sonju J J, Dahal A, Singh S S, et al. Peptide-functionalized liposomes as therapeutic and diagnostic tools for cancer treatment. Journal of Controlled Release, 2021, 329: 624-644.
doi: 10.1016/j.jconrel.2020.09.055
pmid: 33010333
|
|
|
[3] |
Wang Q H, Cheng S, Qin F, et al. Application progress of RVG peptides to facilitate the delivery of therapeutic agents into the central nervous system. RSC Advances, 2021, 11(15): 8505-8515.
doi: 10.1039/d1ra00550b
pmid: 35423368
|
|
|
[4] |
Porosk L, Gaidutšik I, Langel Ü. Approaches for the discovery of new cell-penetrating peptides. Expert Opinion on Drug Discovery, 2021, 16(5): 553-565.
doi: 10.1080/17460441.2021.1851187
pmid: 33874824
|
|
|
[5] |
Ma W J, Peng H, Liu K W, et al. Efficacy of dual-targeting combined anti-tuberculosis drug delivery system in the treatment of tuberculous meningitis. Journal of Biomedical Nanotechnology, 2021, 17(10): 2034-2042.
doi: 10.1166/jbn.2021.3169
pmid: 34706803
|
|
|
[6] |
You L H, Wang J, Liu T Q, et al. Targeted brain delivery of rabies virus glycoprotein 29-modified deferoxamine-loaded nanoparticles reverses functional deficits in parkinsonian mice. ACS Nano, 2018, 12(5): 4123-4139.
doi: 10.1021/acsnano.7b08172
pmid: 29617109
|
|
|
[7] |
Tiwari S, Bahadur P. Modified hyaluronic acid based materials for biomedical applications. International Journal of Biological Macromolecules, 2019, 121: 556-571.
doi: S0141-8130(18)34256-9
pmid: 30321638
|
|
|
[8] |
Kuo P H, Teng Y H, Cin A L, et al. Heparan sulfate targeting strategy for enhancing liposomal drug accumulation and facilitating deep distribution in tumors. Drug Delivery, 2020, 27(1): 542-555.
doi: 10.1080/10717544.2020.1745326
|
|
|
[9] |
Chen K R, Zhang Y Z, Zhu L J, et al. Insights into nucleic acid-based self-assembling nanocarriers for targeted drug delivery and controlled drug release. Journal of Controlled Release, 2022, 341: 869-891.
doi: 10.1016/j.jconrel.2021.12.020
|
|
|
[10] |
Huang J, Ma W J, Sun H H, et al. Self-assembled DNA nanostructures-based nanocarriers enabled functional nucleic acids delivery. ACS Applied Bio Materials, 2020, 3(5): 2779-2795.
doi: 10.1021/acsabm.9b01197
pmid: 35025408
|
|
|
[11] |
Meena C L, Singh D, Kizhakeetil B, et al. Triazine-based Janus G-C nucleobase as a building block for self-assembly, peptide nucleic acids, and smart polymers. The Journal of Organic Chemistry, 2021, 86(4): 3186-3195.
doi: 10.1021/acs.joc.0c02530
|
|
|
[12] |
Shani L, Michelson A N, Minevich B, et al. DNA-assembled superconducting 3D nanoscale architectures. Nature Communications, 2020, 11(1): 5697.
doi: 10.1038/s41467-020-19439-9
pmid: 33173061
|
|
|
[13] |
Yu H L, Yang Z H, Li F, et al. Cell-mediated targeting drugs delivery systems. Drug Delivery, 2020, 27(1): 1425-1437.
doi: 10.1080/10717544.2020.1831103
pmid: 33096949
|
|
|
[14] |
Ferreira D, Moreira J N, Rodrigues L R. New advances in exosome-based targeted drug delivery systems. Critical Reviews in Oncology, 2022, 172: 103628.
doi: 10.1016/j.critrevonc.2022.103628
|
|
|
[15] |
Kimiz-Gebologlu I, Oncel S S. Exosomes: large-scale production, isolation, drug loading efficiency, and biodistribution and uptake. Journal of Controlled Release, 2022, 347: 533-543.
doi: 10.1016/j.jconrel.2022.05.027
pmid: 35597405
|
|
|
[16] |
Jiang Y, Wang F B, Wang K, et al. Engineered exosomes: a promising drug delivery strategy for brain diseases. Current Medicinal Chemistry, 2022, 29(17): 3111-3124.
doi: 10.2174/0929867328666210902142015
|
|
|
[17] |
Yuan A R, Ruan L, Jia R D, et al. Tumor exosome-mimicking iron oxide nanoparticles for near infrared-responsive drug delivery. ACS Applied Nano Materials, 2022, 5(1): 996-1002.
doi: 10.1021/acsanm.1c03643
|
|
|
[18] |
Liu L Y, Li Y, Peng H, et al. Targeted exosome coating gene-chem nanocomplex as “nanoscavenger” for clearing α-synuclein and immune activation of Parkinson’s disease. Science Advances, 2020, 6(50): eaba3967.
doi: 10.1126/sciadv.aba3967
|
|
|
[19] |
孙庆雪, 邵伟, 黄桂华. 脂质体制备方法的选择. 中成药, 2010, 32(8): 1397-1401.
|
|
|
[19] |
Sun Q X, Shao W, Huang G H. Selection of preparation methods of liposomes. Chinese Traditional Patent Medicine, 2010, 32(8): 1397-1401.
|
|
|
[20] |
Filipczak N, Pan J Y, Yalamarty S S K, et al. Recent advancements in liposome technology. Advanced Drug Delivery Reviews, 2020, 156: 4-22.
doi: 10.1016/j.addr.2020.06.022
pmid: 32593642
|
|
|
[21] |
Haddadzadegan S, Dorkoosh F, Bernkop-Schnürch A. Oral delivery of therapeutic peptides and proteins: technology landscape of lipid-based nanocarriers. Advanced Drug Delivery Reviews, 2022, 182: 114097.
doi: 10.1016/j.addr.2021.114097
|
|
|
[22] |
Shah S, Dhawan V, Holm R, et al. Liposomes: advancements and innovation in the manufacturing process. Advanced Drug Delivery Reviews, 2020, 154-155: 102-122.
|
|
|
[23] |
Bottcher S E, Lou J C, Best M D. Liposome triggered content release through molecular recognition of inositol trisphosphate. Chemical Communications, 2022, 58(28): 4520-4523.
doi: 10.1039/D2CC00951J
|
|
|
[24] |
Delfi M, Sartorius R, Ashrafizadeh M, et al. Self-assembled peptide and protein nanostructures for anti-cancer therapy: targeted delivery, stimuli-responsive devices and immunotherapy. Nano Today, 2021, 38: 101119.
doi: 10.1016/j.nantod.2021.101119
|
|
|
[25] |
Katyal P, Meleties M, Montclare J K. Self-assembled protein- and peptide-based nanomaterials. ACS Biomaterials Science & Engineering, 2019, 5(9): 4132-4147.
|
|
|
[26] |
Augustine R, Kalva N, Kim H A, et al. PH-responsive polypeptide-based smart nano-carriers for theranostic applications. Molecules, 2019, 24(16): 2961.
doi: 10.3390/molecules24162961
|
|
|
[27] |
Dharmayanti C, Gillam T A, Klingler-Hoffmann M, et al. Strategies for the development of pH-responsive synthetic polypeptides and polymer-peptide hybrids: recent advancements. Polymers, 2021, 13(4): 624.
doi: 10.3390/polym13040624
|
|
|
[28] |
黄晚秋, 高苗苗, 徐源, 等. 多糖纳米载体的自组装制备途径及生物应用. 高分子通报, 2020(10): 21-29.
|
|
|
[28] |
Huang W Q, Gao M M, Xu Y, et al. Self-assembly approach and biological application of polysaccharide nanocarrier. Polymer Bulletin, 2020(10): 21-29.
|
|
|
[29] |
Li Y W, Zhou M, Song Y B, et al. Double-helical assembly of heterodimeric nanoclusters into supercrystals. Nature, 2021, 594(7863): 380-384.
doi: 10.1038/s41586-021-03564-6
|
|
|
[30] |
Hannewald N, Winterwerber P, Zechel S, et al. DNA origami meets polymers:a powerful tool for the design of defined nanostructures. Angewandte Chemie International Edition, 2021, 60(12): 6218-6229.
|
|
|
[31] |
Zhu Y N, Shen R C, Vuong I, et al. Multi-step screening of DNA/lipid nanoparticles and co-delivery with siRNA to enhance and prolong gene expression. Nature Communications, 2022, 13(1): 4282.
doi: 10.1038/s41467-022-31993-y
pmid: 35879315
|
|
|
[32] |
Chen Z W, Hu Q Y, Gu Z. Leveraging engineering of cells for drug delivery. Accounts of Chemical Research, 2018, 51(3): 668-677.
doi: 10.1021/acs.accounts.7b00526
pmid: 29446615
|
|
|
[33] |
Mohale S, Kunde S S, Wairkar S. Biomimetic fabrication of nanotherapeutics by leukocyte membrane cloaking for targeted therapy. Colloids and Surfaces B: Biointerfaces, 2022, 219: 112803.
doi: 10.1016/j.colsurfb.2022.112803
|
|
|
[34] |
Chen Y T, Zhu M R, Huang B T, et al. Advances in cell membrane-coated nanoparticles and their applications for bone therapy. Biomaterials Advances, 2023, 144: 213232.
doi: 10.1016/j.bioadv.2022.213232
|
|
|
[35] |
Oroojalian F, Beygi M, Baradaran B, et al. Immune cell membrane-coated biomimetic nanoparticles for targeted cancer therapy. Small, 2021, 17(12): 2006484.
doi: 10.1002/smll.v17.12
|
|
|
[36] |
Wang H J, Liu Y, He R Q, et al. Cell membrane biomimetic nanoparticles for inflammation and cancer targeting in drug delivery. Biomaterials Science, 2020, 8(2): 552-568.
doi: 10.1039/c9bm01392j
pmid: 31769765
|
|
|
[37] |
邢昊楠, 陆梅, 刘瑛琪, 等. 基于外泌体的抗肿瘤药物靶向递送的研究进展. 药学学报, 2022, 57(1): 150-158.
|
|
|
[37] |
Xing H N, Lu M, Liu Y Q, et al. Research progress of exosomes based targeted delivery of antitumor drugs. Acta Pharmaceutica Sinica, 2022, 57(1): 150-158.
|
|
|
[38] |
吴忧, 辛林. 新的药物传递系统: 外泌体作为药物载体递送. 中国生物工程杂志, 2020, 40(9): 28-35.
|
|
|
[38] |
Wu Y, Xin L. New drug delivery system: delivery of exosomes as drug carriers. China Biotechnology, 2020, 40(9): 28-35.
|
|
|
[39] |
Xu Y Q, Fei J B, Li G L, et al. Nanozyme-catalyzed cascade reactions for mitochondria-mimicking oxidative phosphorylation. Angewandte Chemie International Edition, 2019, 58(17): 5572-5576.
|
|
|
[40] |
Kumar S, Karmacharya M, Michael I J, et al. Programmed exosome fusion for energy generation in living cells. Nature Catalysis, 2021, 4(9): 763-774.
doi: 10.1038/s41929-021-00669-z
|
|
|
[41] |
Zhang J W, Li D D, Zhang R, et al. Delivery of microRNA-21-sponge and pre-microRNA-122 by MS 2 virus-like particles to therapeutically target hepatocellular carcinoma cells. Experimental Biology and Medicine, 2021, 246(23): 2463-2472.
doi: 10.1177/15353702211035689
|
|
|
[42] |
Olszewska-Widdrat A, Bennet M, Mickoleit F, et al. Bacteriophage-templated assembly of magnetic nanoparticles and their actuation potential. ChemNanoMat, 2021, 7(8): 942-949.
doi: 10.1002/cnma.v7.8
|
|
|
[43] |
Yang G Z, Liu Y, Jin S, et al. Development of core-shell nanoparticle drug delivery systems based on biomimetic mineralization. ChemBioChem, 2020, 21(20): 2871-2879.
doi: 10.1002/cbic.v21.20
|
|
|
[44] |
Zhang M J, Huang Y Y. siRNA modification and delivery for drug development. Trends in Molecular Medicine, 2022, 28(10): 892-893.
doi: 10.1016/j.molmed.2022.08.003
|
|
|
[45] |
Zhang X P, Goel V, Robbie G J. Pharmacokinetics of patisiran, the first approved RNA interference therapy in patients with hereditary transthyretin-mediated amyloidosis. The Journal of Clinical Pharmacology, 2020, 60(5): 573-585.
doi: 10.1002/jcph.v60.5
|
|
|
[46] |
Titze-de-Almeida S S, de Paula Brandão P R, Faber I, et al. Leading RNA interference therapeutics part 1: silencing hereditary transthyretin amyloidosis, with a focus on patisiran. Molecular Diagnosis & Therapy, 2020, 24(1): 49-59.
|
|
|
[47] |
Scott L J. Givosiran: first approval. Drugs, 2020, 80(3): 335-339.
doi: 10.1007/s40265-020-01269-0
pmid: 32034693
|
|
|
[48] |
Agarwal S, Simon A R, Goel V, et al. Pharmacokinetics and pharmacodynamics of the small interfering ribonucleic acid, givosiran, in patients with acute hepatic porphyria. Clinical Pharmacology & Therapeutics, 2020, 108(1): 63-72.
|
|
|
[49] |
Liu L Y, Li Y, Liu R Y, et al. Switchable nanoparticle for programmed gene-chem delivery with enhanced neuronal recovery and CT imaging for neurodegenerative disease treatment. Materials Horizons, 2019, 6(9): 1923-1929.
doi: 10.1039/C9MH00482C
|
|
|
[50] |
Liao X, Liu Y D, Zheng J R, et al. Diverse pathways of engineered nanoparticle-induced NLRP 3 inflammasome activation. Nanomaterials, 2022, 12(21): 3908.
doi: 10.3390/nano12213908
|
|
|
[51] |
Liu H H, Han Y B, Wang T T, et al. Targeting microglia for therapy of Parkinson’s disease by using biomimetic ultrasmall nanoparticles. Journal of the American Chemical Society, 2020, 142(52): 21730-21742.
doi: 10.1021/jacs.0c09390
|
|
|
[52] |
Zhao L W, Gu C Y, Gan Y, et al. Exosome-mediated siRNA delivery to suppress postoperative breast cancer metastasis. Journal of Controlled Release, 2020, 318: 1-15.
doi: S0168-3659(19)30723-0
pmid: 31830541
|
|
|
[53] |
Lin X B, Lin L G, Wu J Y, et al. A targeted siRNA-loaded PDL1-exosome and functional evaluation against lung cancer. Thoracic Cancer, 2022, 13(11): 1691-1702.
doi: 10.1111/1759-7714.14445
pmid: 35545838
|
|
|
[54] |
吕慧中, 赵晨辰, 朱链, 等. 外泌体靶向递药在肿瘤治疗中的进展. 中国生物工程杂志, 2021, 41(5): 79-86.
|
|
|
[54] |
Lv H Z, Zhao C C, Zhu L, et al. Progress of using exosome for drug targeted delivery in tumor therapy. China Biotechnology, 2021, 41(5): 79-86.
|
|
|
[55] |
任磊, 程科满, 张强, 等. 病毒样颗粒在肿瘤治疗中的研究进展. 厦门大学学报(自然科学版), 2021, 60(2): 306-314.
|
|
|
[55] |
Ren L, Cheng K M, Zhang Q, et al. Research progress of virus-like particles in tumor therapy. Journal of Xiamen University (Natural Science), 2021, 60(2): 306-314.
|
|
|
[56] |
Park J H, Mohapatra A, Zhou J R, et al. Virus-mimicking cell membrane-coated nanoparticles for cytosolic delivery of mRNA. Angewandte Chemie International Edition, 2022, 61(2): e202113671.
|
|
|
[57] |
施逸凡, 陶冶, 石艳春, 等. 病毒样颗粒疫苗在疾病防治中的研究进展. 中国免疫学杂志, 2021, 37(5): 618-624.
|
|
|
[57] |
Shi Y F, Tao Y, Shi Y C, et al. Research progress of virus-like particles-based vaccines in disease prevention and treatment. Chinese Journal of Immunology, 2021, 37(5): 618-624.
|
|
|
[58] |
Wang L, Wang X Y, Yang F M, et al. Systemic antiviral immunization by virus-mimicking nanoparticles-decorated erythrocytes. Nano Today, 2021, 40: 101280.
doi: 10.1016/j.nantod.2021.101280
|
|
|
[59] |
Sekhon U D S, Swingle K, Girish A, et al. Platelet-mimicking procoagulant nanoparticles augment hemostasis in animal models of bleeding. Science Translational Medicine, 2022, 14(629): eabb8975.
doi: 10.1126/scitranslmed.abb8975
|
|
|
[60] |
Riazifar M, Mohammadi M R, Pone E J, et al. Stem cell-derived exosomes as nanotherapeutics for autoimmune and neurodegenerative disorders. ACS Nano, 2019, 13(6): 6670-6688.
doi: 10.1021/acsnano.9b01004
pmid: 31117376
|
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