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| Application of Graphene Oxide in Bone Tissue Engineering |
JI Yu-jie,QIN Han,XIANG Xue-rong( ) |
| Stomatological Hospital of Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing 401147, China |
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Abstract Traditional bone tissue engineering scaffold materials have disadvantages, such as insufficient strength and low bioactivity. In recent years, nanomaterials have shown many unique advantages in bone regeneration. Graphene oxide (GO), an oxidized form of graphene, is a representative two-dimensional nanomaterial. Many studies have shown that GO has excellent mechanical properties, good biocompatibility, large specific surface area and easy modification.GO can not only directly promote the adhesion, proliferation and differentiation of stem cells, but also improve the mechanical properties, biological activity, antibacterial ability and immunomodulatory ability of traditional scaffolds. GO-based composite materials are expected to become ideal scaffolds for bone regeneration. This paper first describes the physicochemical properties, biocompatibility, biodegradation and clearance of GO. Then,the latest applications of GO as coatings, controlled release agents and composite scaffolds in bone tissue engineering were summarized. At last, the advantages and challenges of GO are analyzed, and the future research direction is forecasted.
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Received: 24 October 2022
Published: 04 May 2023
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