Induction and Regulation of Cellulase Synthesis in <i>Trichoderma reesei</i>

doi:10.13523/j.cb.2207035

China Biotechnology

2022, Vol. 42

Issue (10): 93-104 DOI: 10.13523/j.cb.2207035

Induction and Regulation of Cellulase Synthesis in Trichoderma reesei

Xiang-zhi LIU¹,Chi CHENG^1,^2,^**(

),Yue ZHAO¹,Chao-jun WANG²,Ying ZHANG²,Chuang XUE^1,^2,^**(

)

1. School of Bioengineering, Dalian University of Technology, Engineering Research Center of Application and Transformation for Synthetic Biology, Dalian 116024, China
2. Ningbo Institute of Dalian University of Technology, Ningbo 315016, China

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Abstract

With the rise of green chemistry, research on the transformation and utilization of natural cellulose raw materials has been highly valued and widely applied. Cellulose degradation by cellulase has paved the way for fuel ethanol and biodiesel production. However, the high production cost of cellulase limits its industrial application. Trichoderma reesei is a cellulase-producing strain and produces abundant cellulase components. Comprehensive studies on the mechanism of cellulase induction and expression regulation of Trichoderma reesei are helpful to improve its cellulase production. In recent years great progress has been made on the induction process and regulation mechanism of cellulase production by Trichoderma reesei. This review summarizes recent progresses of the regulation of cellulase induction and gene expression by Trichoderma reesei, by first introducing the inducers (cellulose, cellobiose, sophorose, lactose, etc.) and their transporters, then summarizing the regulation function of several transcription factors, and moreover, the effects of chromosomal regulation, signaling pathway, and illumination conditions on cellulase induction are also introduced. Finally, the future research directions of cellulase induction in Trichoderma reesei was discussed, including exploring the nature and specific process of inducers, revealing the relationship between transcription factors and transcriptional regulatory network, searching for key functional proteins of signal transduction, and studying the effect of environmental factors on cellulase induction.

Key words： Cellulase Trichoderma reesei Gene expression regulation Transcription factor

Received: 18 July 2022 Published: 04 November 2022

ZTFLH:

Q819

Corresponding Authors: Chi CHENG,Chuang XUE E-mail: cheng.chi@dlut.edu.cn;xue.1@dlut.edu.cn

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Cite this article:

Xiang-zhi LIU,Chi CHENG,Yue ZHAO,Chao-jun WANG,Ying ZHANG,Chuang XUE. Induction and Regulation of Cellulase Synthesis in Trichoderma reesei. China Biotechnology, 2022, 42(10): 93-104.

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https://manu60.magtech.com.cn/biotech/10.13523/j.cb.2207035 OR https://manu60.magtech.com.cn/biotech/Y2022/V42/I10/93

Fig.1 Schematic diagram of Trichoderma reesei cellulase synthesis induction and regulation

Table 1 Transcriptional regulatory factors and their functions in Trichoderma reesei


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