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Advances in the Production of Chemicals from Lignocellulosic Material by Yarrowia lipolytica |
WANG Lu-xin1,2,FANG Li-xia1,CHEN Ya-ru1,LI Meng-xu1,NIU Xiao-long1,2,SONG Hao1,2,CAO Ying-xiu1,**() |
1 Frontier Science Center for Synthetic Biology, Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China 2 Qingdao Institute for Ocean Engineering of Tianjin University, Qingdao 266237, China |
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Abstract Yarrowia lipolytica has great application potential in the field of microbial fermentation of chemicals due to its clear genetic background, relatively mature molecular manipulation system, strong stress resistance, broad substrate spectrum, and strong organic acid and protein secretion capabilities. Lignocellulose is the most abundant renewable biomass resource on the earth, and the use of lignocellulose materials to replace fossil materials to produce chemicals is of great significance in alleviating global energy crisis and ensuring food security. Y. lipolytica can naturally metabolize glucose produced by hydrolysis of lignocellulose. However, the utilization efficiency of other hydrolysis products such as xylose is extremely low. This article reviews the metabolic pathways and engineering strategies of Y. lipolytica using lignocellulosic materials, as well as examples of using lignocellulosic materials to produce chemicals, and focuses on the bottlenecks in this process. The solutions to these bottlenecks were also discussed, with the aim to provide useful information for relevant studies in this field.
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Received: 26 April 2022
Published: 05 January 2023
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Corresponding Authors:
Ying-xiu CAO
E-mail: caoyingxiu@tju.edu.cn
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