Please wait a minute...

中国生物工程杂志

China Biotechnology
China Biotechnology  2022, Vol. 42 Issue (9): 124-132    DOI: 10.13523/j.cb.2204058
    
Development Trend of Biosensors Based on Patent Analysis
WANG Cheng1,GAO Qian1,ZHANG Ling-kai1,SHI Jian-guo2,CHEN Yu-bao3,4,**()
1. Wuhan Library, Chinese Academy of Sciences, Wuhan 430071, China
2. Biology Institute of Shandong Academy of Sciences, Jinan 250103, China
3. Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences, Beijing 100021, China
4. Chinese Society of Biotechnology, Beijing 100101, China
Download: HTML   PDF(3329KB) HTML
Export: BibTeX | EndNote (RIS)      

Abstract  

Biosensor is immobilized biosensitive material as identification element, which has the characteristics of small size, high specificity, fast response and high accuracy, possessing a broad market application prospect. In recent years, biosensor technology has developed rapidly, and research achievements have emerged continuously. In order to better understand the research status of China’s biosensor industry and further promote its healthy development, based on the IncoPat patent database, ITGinsight is used as a literature analysis tool. The overall research situation, regional layout, technical composition and research hotspots in the field of internal biosensors are analyzed, and the core patents are identified. The results show that although China ranks first in the world in the number of biosensor patents, there are problems such as unbalanced regional distribution of scientific research strength, weak research and development strength of enterprises, and inadequate mastery of key core technologies. Finally, corresponding countermeasures are put forward according to the shortcomings of biosensor research in China, which can provide reference for the rapid development strategy of biosensor technology in China.



Key wordsBiosensor      Literature analysis      Patent analysis      Core patents     
Received: 22 April 2022      Published: 10 October 2022
ZTFLH:  G255TP212  
Corresponding Authors: Yu-bao CHEN     E-mail: chenyubao@cnilas.org
Cite this article:

WANG Cheng,GAO Qian,ZHANG Ling-kai,SHI Jian-guo,CHEN Yu-bao. Development Trend of Biosensors Based on Patent Analysis. China Biotechnology, 2022, 42(9): 124-132.

URL:

https://manu60.magtech.com.cn/biotech/10.13523/j.cb.2204058     OR     https://manu60.magtech.com.cn/biotech/Y2022/V42/I9/124

Fig.1 Structure of the biosensor
Fig.2 Annual distribution of patent applications in the field of biosensors
Fig.3 Patents in the field of biosensors are publicly ranked
Fig. 4 Global ranking of patent applicants in the field of biosensors
Fig.5 China ranking of patent applicants in the field of biosensors
Fig.6 Ranking of Chinese provinces and cities in the field of patent applications in the field of biosensors
Fig.7 The technology composition of the world biosensor field
序号 IPC分类号(大组) 含义说明
1 G01N27 用电、电化学或磁的方法测试或分析材料(G01N3/00至G01N25/00优先;电或磁变量的测量或试验,材料的电磁性能的测试或试验入G01R)
2 G01N33 利用不包括在G01N1/00至G01N31/00组中的特殊方法来研究或分析材料
3 C12Q1 包含酶、核酸或微生物的测定或检验方法(带有条件测量或传感器的测定或试验装置,如菌落计数器入C12M1/34);其组合物;这种组合物的制备方法
4 G01N21 利用光学手段,即利用亚毫米波、红外光、可见光或紫外光来测试或分析材料(G01N 3/00至G01N 19/00优先)
5 A61B5 用于诊断目的的测量(放射诊断入A61B6/00;超声波、声波或次声波诊断入A61B8/00);人的辨识
6 C12M1 酶学或微生物学装置
7 C12N15 突变或遗传工程;遗传工程涉及的DNA或RNA,载体(如质粒)或其分离、制备或纯化;所使用的宿主(突变体或遗传工程制备的微生物本身入C12N1/00、C12N5/00、C12N7/00;新的植物入A01H;用组织培养技术再生植物入A01H4/00;新的动物入A01K67/00;含有插入活体细胞的遗传物质以治疗遗传疾病的药剂的应用,基因疗法入A61K48/00,一般肽入C07K)
8 C07K14 具有多于20个氨基酸的肽;促胃液素;生长激素释放抑制因子;促黑激素;其衍生物
9 B01L3 实验室用的容器或器皿,如实验室玻璃仪器(瓶子入B65D;酶或微生物学用的设备入C12M1/00);点滴器(量体积的容器入G01F)
10 G06K9 用于阅读或识别印刷或书写字符或者用于识别图形,如指纹的方法或装置(用于图表阅读或者将诸如力或现状态的机械参量的图形转换为电信号的方法或装置入G06K11/00;语音识别入G10L15/00)
Table 1 Description of IPC (international) patent classification number (large group) in the field of biosensors
Fig.8 Distribution map of technical topics in the field of biosensors
Fig.9 Technology evolution diagram in the field of biosensors
标题 专利所有人 专利号 申请日期 是否
有效
Enzyme electrode structure Nok Corp US6156173A 2000-01-18
Surgical instruments including MEMS devices Tyco Healthcare
Group Lp
AU2009200903A1 2009-03-06
Biosensor membranes composed of polymers containing heterocyclic nitrogens Thera Sense Inc. US20030042137A1 2002-05-14
Glucose biosensor M. Biotech Inc. US6475750B1 2000-08-23
Healthcare monitoring system Kimberly Clark
Worldwide Inc.
US20040100376A1 2002-11-26
Biosensor, iontophoretic sampling system, and methods of use thereof Cygnus Inc. US20030135100A1 2003-01-29
Anti-inflammatory biosensor for reduced biofouling and enhanced sensor performance Medtronic MiniMed Inc. US20030199837A1 2002-04-22
刺血针一体型传感器、测定装置、生物传感器用盒、以及刺血针一体型传感器用测定装置 松下电器产业株式会社 CN1455654A 2002-01-21
System and method for coding information on a biosensor test strip Beaty Terry US20050279647A1 2005-04-01
传感装置、设备和系统及其操作方法 格拉斯哥大学行政评议会 CN101150985A 2006-02-10
用于实现用于生物传感器的基于阈值的校正函数的方法和装置 拜尔健康护理有限责任公司 CN1938589A 2005-03-31
Porous silicon-polymer composites for biosensor applications Joon Hyung Jin;
Evangelyn C Alocilja
US20090181441A1 2008-11-26
Label-free biosensors based upon distributed feedback laser Brian T Cunningham;
Meng Lu
US20090179637A1 2008-12-29
Miniaturised biosensor with optimized anperimetric detection Diagnoswiss Sa;
Biomerieux Sa
GB0607205D0 2006-04-10
Device and methods for detecting analytes in saliva Koninklijke Philips
Electronics N V
EP2128617A1 2008-05-27
Table 2 Some core patents in the field of biosensors
[1]   武宝利, 张国梅, 高春光, 等. 生物传感器的应用研究进展. 中国生物工程杂志, 2004, 24(7): 65-69.
[1]   Wu B L, Zhang G M, Gao C G, et al. Application and development of biosensors. China Biotechnology, 2004, 24(7): 65-69.
[2]   Kotsiri Z, Vidic J, Vantarakis A. Applications of biosensors for bacteria and virus detection in food and water-A systematic review. Journal of Environmental Sciences, 2022, 111: 367-379.
doi: 10.1016/j.jes.2021.04.009
[3]   Metkar S K, Girigoswami K. Diagnostic biosensors in medicine - a review. Biocatalysis and Agricultural Biotechnology, 2019, 17: 271-283.
doi: 10.1016/j.bcab.2018.11.029
[4]   张先恩. 首届世界生物传感器学术大会简介. 生命的化学(中国生物化学会通讯), 1990, 10(6): 32-33.
[4]   Zhang X E. Introduction to the first world conference on biosensors. Chemistry of Life, 1990, 10(6): 32-33.
[5]   张先恩. 生物传感发展50年及展望. 中国科学院院刊, 2017, 32(12): 1271-1280.
[5]   Zhang X E. Biosensors: 50 years development and future perspectives. Bulletin of Chinese Academy of Sciences, 2017, 32(12): 1271-1280.
[6]   张正燕, 陈钰, 宋丽杰, 等. 场效应晶体管生物传感器在生物医学检测中的应用研究进展. 中国生物工程杂志, 2021, 41(10): 73-88.
[6]   Zhang Z Y, Chen Y, Song L J, et al. Advances in the application of field effect transistor biosensor in biomedical detection. China Biotechnology, 2021, 41(10): 73-88.
[7]   韩雪清, 杨泽晓, 林祥梅. 极具应用前景的生物学检测技术——生物传感器. 中国生物工程杂志, 2008, 28(5): 141-147.
[7]   Han X Q, Yang Z X, Lin X M. A promising biological detection technology-biosensor. China Biotechnology, 2008, 28(5): 141-147.
[8]   邵平, 刘黎明, 吴唯娜, 等. 传感器在果蔬智能包装中的研究与应用. 食品科学, 2021, 42(11): 349-355.
[8]   Shao P, Liu L M, Wu W N, et al. Research and application of sensors in intelligent packaging of fruits and vegetables. Food Science, 2021, 42(11): 349-355.
[9]   Gᶏgała-Borowska I, Karwaciak I, Jaros D, et al. Cyanobacterial cell-wall components as emerging environmental toxicants - detection and holistic monitoring by cellular signaling biosensors. Science of the Total Environment, 2022, 807: 150645.
doi: 10.1016/j.scitotenv.2021.150645
[10]   王燕鹏, 韩涛, 赵亚娟, 等. 人工智能领域关键技术挖掘分析. 世界科技研究与发展, 2019, 41(4): 368-379.
[10]   Wang Y P, Han T, Zhao Y J, et al. Mining and analysis of key technologies in artificial intelligence. World Sci-Tech R & D, 2019, 41(4): 368-379.
[11]   刘玉琴, 汪雪锋, 雷孝平. 科研关系构建与可视化系统设计与实现. 图书情报工作, 2015, 59(8): 103-110, 125.
doi: 10.13266/j.issn.0252-3116.2015.08.015
[11]   Liu Y Q, Wang X F, Lei X P. Design and implementation of academic relation and visualization system. Library and Information Service, 2015, 59(8): 103-110, 125.
doi: 10.13266/j.issn.0252-3116.2015.08.015
[12]   王晓光, 程齐凯. 基于NEViewer的学科主题演化可视化分析. 情报学报, 2013, 32(9): 900-911.
[12]   Wang X G, Cheng Q K. Analysis on evolution of research topics in a discipline based on NEViewer. Journal of the China Society for Scientific and Technical Information, 2013, 32(9): 900-911.
[13]   郭文娟, 刘玉琴, 孙源, 等. 基于专利分析的PCD超硬刀具发展态势研究. 中国材料进展, 2021, 40(6): 446-453.
[13]   Guo W J, Liu Y Q, Sun Y, et al. Study on the development of global polycrystalline diamond superhard cutting tool based on patent analysis. Materials China, 2021, 40(6): 446-453.
[14]   李军华, 陆亦恺, 尹若元. 公司专利信息搜索技巧. 情报探索, 2012(4): 76-82.
[14]   Li J H, Lu Y K, Yin R Y. Company patent information search skills. Information Research, 2012(4): 76-82.
[1] ZHANG Jing-qi,WANG Sheng. Development Trend of 3D Bioprinting Industry Based on Patent Analysis[J]. China Biotechnology, 2022, 42(6): 102-115.
[2] ZHU Shu,ZHU Li-feng,YANG Shuo,JIN Ran,WANG Yu-sheng,SUN Bao-quan. Applications of Silicon Nanowires in Biosensors:A Review[J]. China Biotechnology, 2022, 42(1/2): 174-181.
[3] XU Wen-juan,SONG Dan,CHEN Dan,LONG Hui,CHEN Yu-bao,LONG Feng. Research Progress of Pathogen Detection Technologies Based on CRISPR/CAS Biosensor[J]. China Biotechnology, 2021, 41(8): 67-74.
[4] TANG Meng-tong,WANG Zhao-guan,LI Jiao-jiao,QI Hao. Application of Terminal Deoxynucleotidyl Transferase in Biosensors and Nucleic Acid Synthesis[J]. China Biotechnology, 2021, 41(5): 51-64.
[5] CHEN Ying,LI Qian. Patent Analysis on the Development Trend of Industrial Application of Special Yeast[J]. China Biotechnology, 2021, 41(4): 91-99.
[6] ZHANG Zheng-yan,CHEN Yu,SONG Li-jie,SU Zheng-quan,ZHANG Hai-yan. Advances in the Application of Field Effect Transistor Biosensor in Biomedical Detection[J]. China Biotechnology, 2021, 41(10): 73-88.
[7] HAO Xiao-ting,LIU Jun-jie,DENG Yu-lin,ZHANG Yong-qian. Radiation Biosensor Based on Promoter of SOS Reaction and Oxidative Stress Reaction[J]. China Biotechnology, 2020, 40(7): 30-40.
[8] CHENG Ping,ZHANG Yang-zi,MA Xuan,CHEN Xu,ZHU Bao-qing,XU Wen-tao. Properties and Applications of Stimuli-Responsive DNA Hydrogels[J]. China Biotechnology, 2020, 40(3): 132-143.
[9] JIANG Tian,ZHANG Chao,LIU Hui-zhou. Development Trends Analysis of Microbial Fuel Cell[J]. China Biotechnology, 2020, 40(1-2): 189-197.
[10] XIE Hua-ling,LV Lu-cheng,YANG Yan-ping. Patent Analysis of Global Coronavirus Vaccine[J]. China Biotechnology, 2020, 40(1-2): 57-64.
[11] HUANG Peng-fei,CHEN Yun,LU Jiao,MAO Kai-yun,YUAN Yin-chi. Development Situation and Suggestions of Biomedicine Patent-intensive Industry, Based on the Case Study of Shanghai[J]. China Biotechnology, 2020, 40(12): 108-116.
[12] LI Hang,WANG Tong. Research Progress on Overcoming Debye Screening Effect of Silicon Nanowire Field-effect Transistor Biosensor[J]. China Biotechnology, 2019, 39(10): 112-116.
[13] Qing BI,Lin SUN. Analysis and Comparison of Foreign and Chinese Patent Applications in Chimeric Antigen Receptor T Cell (CAR-T) Technology[J]. China Biotechnology, 2018, 38(4): 107-114.
[14] YI Yu, WANG Min-jun, MEI Jian-feng, CHEN Jian-shu, ZHANG Yan-lu, YING Guo-qing. Construction and Characterization of Electrochemical Biosensor based on Endotoxin Aptameer[J]. China Biotechnology, 2017, 37(8): 46-50.
[15] WEN Guo-xia, HUANG Zi-hao, TAN Jun-jie, KAN Nai-peng, LING Jing-yi, ZHANG Xia, LIU Gang, CHEN Hui-peng. Construction of XylR-Pugene Lines in Escherichia coli to Detect 2,4,6-trinitrotoluene[J]. China Biotechnology, 2017, 37(7): 105-114.