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| Research Progress of Exosomes Derived from Bone Marrow Mesenchymal Stem Cells and Their Related Signal Pathways in Steroid-induced Necrosis of the Femoral Head |
Xu-kun BI1,Cheng-long GUO2,**( ),Jian-dong ZHAO1,Xing-quan REN1,Wei-tao CHAI1 |
1. Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China
2. Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China |
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Abstract Bone marrow mesenchymal stem cells are a kind of stem cells with multi-directional differentiation ability. In recent years, relevant studies have found that the exosomes secreted by bone marrow mesenchymal stem cells promote the repair of injured tendons and angiogenesis, inhibit oxidative stress response, protect neurons, promote cartilage regeneration, and regulate bone metabolism in addition to its other functions. Steroid-induced femoral head necrosis is a kind of aseptic necrosis of the femoral head caused by massive use of hormones. Its specific mechanism has not been clarified, and related signal pathways play a key role, such as Wnt/ β- catenin, RANKL-RANK, PTEN/AKT, PI3K/AKT and other pathways, and the activation of these signal pathways is closely related to exosomes. This article reviews the relevant research progress of exosomes from bone marrow mesenchymal stem cells and related signal pathways in steroid-induced femoral head necrosis, in order to have certain guiding significance for the prevention and treatment of steroid-induced femoral head necrosis and the development of related drugs.
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Received: 26 March 2022
Published: 04 November 2022
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Corresponding Authors:
Cheng-long GUO
E-mail: 107228466@qq.com
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