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| Research Progress of Supercritical Carbon Dioxide Technology in Tissue Engineering Scaffolds |
XIE Jia-xuan,LIU Xuan**( ),LIU Gang**() |
| Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China |
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Abstract As one of the three major elements in tissue engineering research, tissue engineering scaffolds provide an excellent environment for cell attachment, migration and proliferation. Traditional preparation techniques of polymeric scaffolds for tissue engineering, such as particle leaching, phase inversion and electrospinning, are relatively mature in theory and technology, but since most of them require the participation of organic solvents, there are still problems in the process, like the residual organic solvents, the control of holes and the poor connectivity. Supercritical carbon dioxide (SC-CO2) has a density similar to that of a liquid, while its viscosity and diffusion coefficient is closer to that of a gas, respectively, and it possesses a special performance of physical and chemical properties like strong fluidity, large dissolving power, and high heat transfer efficiency. Combining with traditional technology, it can effectively circumvent the problems mentioned above in a green and gentle system, which has broad prospects in the scaffolds preparation of tissue engineering and drug loading.
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Received: 11 November 2021
Published: 05 May 2022
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Corresponding Authors:
Xuan LIU,Gang LIU
E-mail: liuxuan@xmu.edu.cn;gangliu.cmitm@xmu.edu.cn
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| [1] |
Langer R, Vacanti J. Advances in tissue engineering. Journal of Pediatric Surgery, 2016, 51(1): 8-12.
doi: 10.1016/j.jpedsurg.2015.10.022
|
|
|
| [2] |
Langer R, Vacanti J P. Tissue engineering. Science, 1993, 260(5110): 920-926.
doi: 10.1126/science.8493529
pmid: 8493529
|
|
|
| [3] |
Guan G, da Huo, Li Y Z, et al. Engineering hiPSC-CM and hiPSC-EC laden 3D nanofibrous splenic hydrogel for improving cardiac function through revascularization and remuscularization in infarcted heart. Bioactive Materials, 2021, 6(12): 4415-4429.
doi: 10.1016/j.bioactmat.2021.04.010
pmid: 33997517
|
|
|
| [4] |
Stevens K R, Scull M A, Ramanan V, et al. In situ expansion of engineered human liver tissue in a mouse model of chronic liver disease. Science Translational Medicine, 2017, 9(399): eaah5505.
doi: 10.1126/scitranslmed.aah5505
|
|
|
| [5] |
Orive G, Hernández R M, Gascón A R, et al. Cell encapsulation: promise and progress. Nature Medicine, 2003, 9 (1): 104-10.
doi: 10.1038/nm0103-104
|
|
|
| [6] |
Mandal B B, Kundu S C. Cell proliferation and migration in silk fibroin 3D scaffolds. Biomaterials, 2009, 30(15): 2956-2965.
doi: 10.1016/j.biomaterials.2009.02.006
pmid: 19249094
|
|
|
| [7] |
贾超. 超临界流体技术制备组织工程三维多孔支架工艺研究. 石家庄: 河北科技大学, 2014.
|
|
|
| [7] |
Jia C. Research on preparation of3D porous scaffold of tissue engineering based on supercritical fluid technology. Shijiazhuang: Hebei University of Science and Technology, 2014
|
|
|
| [8] |
王身国, 杨健, 蔡晴, 等. 组织工程用生物材料及细胞支架研究进展. 中华整形外科杂志, 2000(6): 328-330.
|
|
|
| [8] |
Wang S G, Yang J, Cai Q, et al. Research progress of biomaterials and cell scaffolds for tissue engineering. Chinese Journal of Plastic Surgery and Burns, 2000(6): 328-330.
|
|
|
| [9] |
Draghi L, Resta S, Pirozzolo M G, et al. Microspheres leaching for scaffold porosity control. Journal of Materials Science Materials in Medicine, 2005, 16(12): 1093-1097.
doi: 10.1007/s10856-005-4711-x
|
|
|
| [10] |
Whang K, Goldstick T K, Healy K E. A biodegradable polymer scaffold for delivery of osteotropic factors. Biomaterials, 2000, 21(24): 2545-2551.
pmid: 11071604
|
|
|
| [11] |
Hong J, Yeo M, Yang G H, et al. Cell-electrospinning and its application for tissue engineering. International Journal of Molecular Sciences, 2019, 20(24): 6208.
doi: 10.3390/ijms20246208
|
|
|
| [12] |
Zhu W, Ma X Y, Gou M L, et al. 3D printing of functional biomaterials for tissue engineering. Current Opinion in Biotechnology, 2016, 40: 103-112.
doi: 10.1016/j.copbio.2016.03.014
|
|
|
| [13] |
Barry J J A, Silva M M C G, Popov V K, et al. Supercritical carbon dioxide: putting the fizz into biomaterials. Philosophical Transactions Series A, Mathematical, Physical, and Engineering Sciences, 2016, 364(1838): 249-261.
|
|
|
| [14] |
聂凌鸿, 周如金, 彭华松, 等. 超临界二氧化碳的应用研究. 林产化工通讯, 2003, 37(3): 29-34.
|
|
|
| [14] |
Nie L H, Zhou R J, Peng H S, et al. Application study on supercritical carbon dioxide. Journal of Chemical Industry of Forest Products (Bimonthly), 2003, 37(3): 29-34.
|
|
|
| [15] |
Verónico Sánchez F J, Elizalde Solis O, Zamilpa A, et al. Extraction of galphimines from Galphimia glauca with supercritical carbon dioxide. Molecules (Basel, Switzerland), 2020, 25(3): 477.
doi: 10.3390/molecules25030477
|
|
|
| [16] |
White A, Burns D, Christensen T W. Effective terminal sterilization using supercritical carbon dioxide. Journal of Biotechnology, 2006, 123(4): 504-515.
doi: 10.1016/j.jbiotec.2005.12.033
|
|
|
| [17] |
冯超, 王瑜, 孔令镕, 等. 超临界CO2萃取修复污染土壤的发展与展望. 现代化工, 2020, 40(5): 23-27, 31.
|
|
|
| [17] |
Feng C, Wang Y, Kong L R, et al. Advances on supercritical CO2 extraction for remediation of contaminated soil. Modern Chemical Industry, 2020, 40(5): 23-27, 31.
|
|
|
| [18] |
董力. 超临界二氧化碳发电技术概述. 中国环保产业, 2017(5): 48-52.
|
|
|
| [18] |
Dong L. Summarization on power technology of supercritical carbon dioxide. China Environmental Protection Industry, 2017(5): 48-52.
|
|
|
| [19] |
Campardelli R, Baldino L, Reverchon E. Supercritical fluids applications in nanomedicine. The Journal of Supercritical Fluids, 2015, 101: 193-214.
doi: 10.1016/j.supflu.2015.01.030
|
|
|
| [20] |
Dunham M. Supercritical Carbon Dioxide Cycles for Generation IV Nuclear Reactors. 2022. http://large.stanford.edu/courses/2014/ph241/dunham1/.
|
|
|
| [21] |
Levit N, Tepper G. Supercritical CO2-assisted electrospinning. The Journal of Supercritical Fluids, 2004, 31(3): 329-333.
doi: 10.1016/j.supflu.2003.12.008
|
|
|
| [22] |
Wahyudiono, Machmudah S, Kanda H, et al. Formation of PVP hollow fibers by electrospinning in one-step process at sub and supercritical CO2. Chemical Engineering and Processing: Process Intensification, 2014, 77: 1-6.
doi: 10.1016/j.cep.2013.12.007
|
|
|
| [23] |
Baldino L, Cardea S, Reverchon E. A supercritical CO2 assisted electrohydrodynamic process used to produce microparticles and microfibers of a model polymer. Journal of CO2 Utilization, 2019, 33: 532-540.
|
|
|
| [24] |
刘倩倩. 超临界二氧化碳发泡技术制备PLGA多孔组织工程支架研究. 杭州: 浙江大学, 2013.
|
|
|
| [24] |
Liu Q Q. Fabrication of porous PLGA scaffolds using supercritical carbon dioxide for application in tissue engineering. Hangzhou: Zhejiang University, 2013.
|
|
|
| [25] |
García-González C A, Barros J, Rey-Rico A, et al. Antimicrobial properties and osteogenicity of vancomycin-loaded synthetic scaffolds obtained by supercritical foaming. ACS Applied Materials & Interfaces, 2018, 10(4): 3349-3360.
|
|
|
| [26] |
Liu P, Chen W, Liu C, et al. A novel poly (vinyl alcohol)/poly (ethylene glycol) scaffold for tissue engineering with a unique bimodal open-celled structure fabricated using supercritical fluid foaming. Scientific Reports, 2019, 9: 9534.
doi: 10.1038/s41598-019-46061-7
|
|
|
| [27] |
Savaris M, Garcia C S C, Roesch-Ely M, et al. Polyurethane/poly(d, l-lactic acid) scaffolds based on supercritical fluid technology for biomedical applications: studies with L929 cells. Materials Science & Engineering C, Materials for Biological Applications, 2019, 96: 539-551.
|
|
|
| [28] |
马腾, 陈爱政, 王士斌. 超临界二氧化碳流体发泡技术制备组织工程支架及其泡孔形貌控制研究进展. 中国生物医学工程学报, 2014, 33(4): 467-474.
|
|
|
| [28] |
Ma T, Chen A Z, Wang S B. Research progress in study of tissue engineering scaffolds and their pore morphologies by supercritical CO2 foaming technology. Chinese Journal of Biomedical Engineering, 2014, 33(4): 467-474.
|
|
|
| [29] |
Cardea S, de Marco I. Cellulose acetate and supercritical carbon dioxide: membranes, nanoparticles, microparticles and nanostructured filaments. Polymers, 2020, 12(1): 162.
doi: 10.3390/polym12010162
|
|
|
| [30] |
刘学武, 陈淑花, 詹世平. 超临界CO2诱导相转化法制备聚苯乙烯膜及膜体系的相图计算. 高等学校化学学报, 2016, 37(8): 1573-1579.
|
|
|
| [30] |
Liu X W, Chen S H, Zhan S P. Experimental study and theoretical phase diagram calculation for polystyrene membranes prepared by supercritical CO2-induced phase inversion†. Chemical Journal of Chinese Universities, 2016, 37(8): 1573-1579.
|
|
|
| [31] |
Deng A H, Chen A Z, Wang S B, et al. Porous nanostructured poly-l-lactide scaffolds prepared by phase inversion using supercritical CO2 as a nonsolvent in the presence of ammonium bicarbonate particles. The Journal of Supercritical Fluids, 2013, 77: 110-116.
doi: 10.1016/j.supflu.2013.02.020
|
|
|
| [32] |
蔡佩. 超临界流体辅助制备负载型离子液体及其CO2吸附性能. 大连: 大连理工大学, 2017.
|
|
|
| [32] |
Cai P. Preparation of supported ionic liquid using supercritical fluid and CO2 adsorption properties. Dalian: Dalian University of Technology, 2017.
|
|
|
| [33] |
Duarte A R C, Mano J F, Reis R L. Perspectives on: supercritical fluid technology for 3D tissue engineering scaffold applications. Journal of Bioactive and Compatible Polymers, 2009, 24(4): 385-400.
doi: 10.1177/0883911509105796
|
|
|
| [34] |
Yoda S, Sato K, Oyama H T. Impregnation of paclitaxel into poly(dl-lactic acid) using high pressure mixture of ethanol and carbon dioxide. RSC Advances, 2011, 1(1): 156.
doi: 10.1039/c1ra00070e
|
|
|
| [35] |
Tang C, Guan Y X, Yao S J, et al. Preparation of ibuprofen-loaded chitosan films for oral mucosal drug delivery using supercritical solution impregnation. International Journal of Pharmaceutics, 2014, 473(1-2): 434-441.
doi: 10.1016/j.ijpharm.2014.07.039
|
|
|
| [36] |
Cabezas L I, Gracia I, García M T, et al. Production of biodegradable porous scaffolds impregnated with 5-fluorouracil in supercritical CO2. The Journal of Supercritical Fluids, 2013, 80: 1-8.
doi: 10.1016/j.supflu.2013.03.030
|
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