A Review on Structure and Functions of TonB-dependent Receptors in Gram-negative Bacteria

doi:10.13523/j.cb.2110013

China Biotechnology

2022, Vol. 42

Issue (4): 93-101 DOI: 10.13523/j.cb.2110013

A Review on Structure and Functions of TonB-dependent Receptors in Gram-negative Bacteria

WANG Ya-ling^1,^2,³,CHENG An-chun^1,^2,³,LIU Ma-feng^1,^2,^3,^**(

)

1 Institute of Preventive Veterinary Medicine, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
2 Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
3 Key Laboratory of Animal Disease and Human Health of Sichuan Province, Chengdu 611130, China

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Abstract

Bacteria need to absorb a variety of nutrients from the outer environments for their survival and replication. The small molecules less than 600 Da can freely pass the outer membrane of the gram-negative bacteria. However, for the transportation of the large size of nutrients, the TonB-dependent receptors of gram-negative bacteria are required. TonB-dependent receptors have been found to be present in all the sequenced gram-negative bacteria, but the number of TonB dependent receptors and their functions are various in different bacteria. It has been shown that TonB-dependent receptors were not only involved in the transportation of many different nutrients, such as iron, heme, manganese, zinc, vitamin, and carbohydrate, but also the secretion of protease. This review provided detailed information about the functions and structure of TonB-dependent receptors from different gram-negative bacteria. It will be helpful for the further understanding of the new functions of TonB-dependent receptors.

Key words： Gram-negative bacteria TonB-dependent receptor Function

Received: 13 October 2021 Published: 05 May 2022

ZTFLH:

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Corresponding Authors: Ma-feng LIU E-mail: liumafengra@163.com

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Cite this article:

WANG Ya-ling,CHENG An-chun,LIU Ma-feng. A Review on Structure and Functions of TonB-dependent Receptors in Gram-negative Bacteria. China Biotechnology, 2022, 42(4): 93-101.

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https://manu60.magtech.com.cn/biotech/10.13523/j.cb.2110013 OR https://manu60.magtech.com.cn/biotech/Y2022/V42/I4/93

Table 1 Summary of all known TonB-dependent transporter crystal structures in the Gram-negative bacteria

Fig.1 Structure of TonB-dependent receptor FepA (PDB ID:1FEP) (a),(b) A conversed β-barrel domain at C-terminus (blue) and a plug domain at N-terminus (red) of TonB-dependent receptor (c) Top of TonB-dependent receptor


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