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| Research Progress on the Effect of Gut Microbes on Life Span and Its Mechanism |
LI Xue,MENG Qing-xiong**( ) |
| School of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China |
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Abstract Extending the span of a healthy lifespan is of great significance to everyone. Centenarians have unique characteristics of the intestinal microbiome. The gut microbiome lies at the core of many age-associated changes, and the changes in microbial characteristics and genetic composition can affect longevity. Some diets and drugs cannot play a life-extension effect without the participation of microorganisms, which play an important mediating and transforming role. Probiotics and fecal transplantation and other measures have been confirmed to affect the body’s lifespan in animal models. More and more studies have shown that microorganisms could produce small molecular compounds to promote healthy aging and even prolong individual life spans, such as γ -aminobutyric acid and capsular iso-polysaccharide acid. They also affect host biosynthesis metabolism, such as 5-hydroxytryptamine, and even indirectly participate in the regulation of host signal pathways. At present, there is no systematic summary of the biological functions of these microorganisms and their effects on the host lifespan. The article reviews the evidence and physiological mechanism of intestinal microorganisms’ effects on lifespan, providing a reference for interventions to improve health status in the elderly.
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Received: 20 September 2021
Published: 05 May 2022
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Corresponding Authors:
Qing-xiong MENG
E-mail: qxmeng@sina.com
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