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| Mechanisms of Action of tRNA-derived Small RNAs and Their Potential Roles in Related Diseases |
LIAO Tian-ci,ZHENG Ting,SHEN Lin-yuan,ZHAO Ye,NIU Li-li,ZHANG Shun-hua,ZHU Li**( ) |
| College of Animal Science and Technology, Sichuan Agricultural University, Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China |
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Abstract Recently, tRNA-derived small RNAs (tsRNAs) were gradually recognized as a novel and potential non-coding RNAs (ncRNAs).There are mainly two types of tsRNAs, including tRNA halves (tiRNAs) and tRNA-derived fragments (tRFs), which differ in the cleavage position of the precursor or mature tRNA transcript. Emerging evidence suggests that tsRNAs are implicated in various cellular processes, including translational inhibition, gene silencing, and ribosome biogenesis. They also play an important role in the development of related diseases such as cancer, neurodegeneration, metabolic diseases and viral infections. This review summarizes the functions and mechanisms of action of tsRNAs, the potential application of tsRNAs in related diseases,and the current problems and puts forward future research directions.
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Received: 12 August 2021
Published: 07 April 2022
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Corresponding Authors:
Li ZHU
E-mail: zhuli7508@163.com
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