Advances in the Application of Field Effect Transistor Biosensor in Biomedical Detection

doi:10.13523/j.cb.2105013

China Biotechnology

2021, Vol. 41

Issue (10): 73-88 DOI: 10.13523/j.cb.2105013

Advances in the Application of Field Effect Transistor Biosensor in Biomedical Detection

ZHANG Zheng-yan^1,²,CHEN Yu²,SONG Li-jie²,SU Zheng-quan^1,^**(

),ZHANG Hai-yan^2,^**

1 Guangdong Engineering Research Center of Natural Products and New Drugs, Guangdong Provincial UniversityEngineering Technology Research Center of Natural Products and Drugs, Guangdong Pharmaceutical University,Guangzhou 510006, China
2 Sensor Research Center, General Hospital of Southern Theatre Command of the PLA,Guangzhou 510010, China

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Abstract

Field-Effect Transistor (FET) biosensors have received a lot of attention due to their high sensitivity, fast analysis speed, no labeling, small size and simple operation. They are widely used in the detection of DNA, protein, cell, ion and other biomarkers. In recent years, nanomaterials and microelectronics technologies improve the sensing performance of sensors in sensor design. Field-effect transistor biosensors are developing at an amazing speed in the direction of high sensitivity, miniaturization, rapidness and multi-function. To study the working principle of field-effect transistor biosensors, to explain the latest research progress and applications of field-effect transistor biosensors in the field of biomedical testing in recent years, and to discuss the countermeasures of field-effect transistor biosensors to overcome various shortcomings provide a reference for the development of the sensor in future biomedical testing, which is of great significance to promote its development and application.

Key words： Field-effect transistor Biosensors Biomedical application Analysis and detection

Received: 07 May 2021 Published: 08 November 2021

ZTFLH:

Q819

Corresponding Authors: Zheng-quan SU,Hai-yan ZHANG E-mail: zhanghaiyan1998@126.com

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	Zheng-yan ZHANG
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Cite this article:

ZHANG Zheng-yan,CHEN Yu,SONG Li-jie,SU Zheng-quan,ZHANG Hai-yan. Advances in the Application of Field Effect Transistor Biosensor in Biomedical Detection. China Biotechnology, 2021, 41(10): 73-88.

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https://manu60.magtech.com.cn/biotech/10.13523/j.cb.2105013 OR https://manu60.magtech.com.cn/biotech/Y2021/V41/I10/73

Fig.1 Schematic diagram of basic structure of field effect transistor sensor

Fig.2 Schematic diagram of field effect transistor biosensors

Fig.3 The detection principle of EGFET glucose sensor (a) and its linear range of glucose detection (b)

Fig.4 Wearable 3D-EMG-ISFETs (ISM) functionalized with ion selective membranes (ISMs) for Na⁺, K⁺, and Ca²⁺ sensing (a) Picture of real product (b) Schematic diagram

Fig.5 Principle of graphene nanosensor detecting insulin

Fig.6 Schematic structure of DNA modified thin film field effect device and the principleof DNA-hybridization detection

Fig.7 Schematic representation of the hybridization of PNA-modified ISFET

Fig.8 Structure and principle of function of an enzyme-based thin film field effect device

Fig.9 Schematic representation and detection result of DNA amplification and detection by pH-based sensing semiconductor system (a) Principle of method (b,c) On-chip amplification and detection using pH-PCR and pH-LAMP

Table 1 Research process of immunoFET

Fig.10 Configuration of a SiNW-FET biosensor for measuring electrical activity in cardiomyocytes

Fig.11 Schematic diagram of ABX-GMFET in the dual-channel microfluidics (a) and its detection results for Escherichia coli (b), Salmonella (c), Staphylococcus aureus (d) and Enterococcus faecalis (e) and the real-time response of ABX-GMFET to GNB (f), GPB (g) and the mixture of GNB and GPB (h) in buffer solution


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