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| Research Progress on Overcoming Debye Screening Effect of Silicon Nanowire Field-effect Transistor Biosensor |
LI Hang,WANG Tong( ) |
| Wuxi People’s Hospital Affiliated to Nanjing Medical University,Wuxi 214000,China |
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Abstract Silicon nanowire field-effect transistor(SiNW-FET) biosensor has been successfully used to detect many kinds of biomolecules.such as protein,nucleic acids,carbohydrates,etc.Compared with traditional detection methods,it has the advantages that specificity,label-free,real-time and so on.But Debye screening effect of semiconductor device seriously affect the detection sensitivity of SiNW-FET biosensor to biomolecules in blood sampal,especially for protein molecule. And to a great extent,it hindered the practical application of SiNW-FET biosensor. Therefore,effectively overcoming Debye screening effect is the key for the practical application of SiNW-FET biosensor.Now,the main ways of effectively overcome debye screening effect and achieve protein detection in blood sampal are dilution,desalination,protein purification,using biomolecule-permeable polymer layer,tailoring antibody and using aptamer replace antibody.
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Received: 24 January 2019
Published: 12 November 2019
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Corresponding Authors:
Tong WANG
E-mail: aanti@163.com
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