Antimicrobial Peptides: Current Status and Future Challenges

doi:10.13523/j.cb.20190812

China Biotechnology

2019, Vol. 39

Issue (8): 86-94 DOI: 10.13523/j.cb.20190812

Antimicrobial Peptides: Current Status and Future Challenges

TANG Xin^1,²,MAO Xin-fang³,MA Bin-yun²,GOU Ping^1,^**(

)

1 College of Life Science and Technology, Xinjiang University, ürümqi 830046, China;
2 Keck school of Medicine, University of Southern California, Los Angeles 90033, United States
3 School of Chemical Engineering, Sichuan University of Science and Engineering, Zigong 643000, China

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Abstract

Antimicrobial peptides (AMPs) are produced in various living organisms as first-line host defenses against potential pathogenic microbes in their surroundings. Pioneering studies showed that AMPs can directly interfere with the integrity of the bacterial cell membrane and cell wall though membrane-disruptive mechanism. In addition to interact with membrane, there are increasing evidence to indicate that AMPs have intracellular targets to achieve efficient killing, including nucleic acids binding, inhibiton of protein synthesis and protein-folding, inhibition of cell wall biosynthesis, inhibition of protease and cell division. Due to unique action mechanisms and broad-spectrum of activity, there are continued efforts in exploiting potential applications of AMPs in different area. However, some issues need to be resolved before AMPs be widely used, like AMPs stability, decreased antimicrobial activity and AMPs resistance. In this review, it will be mentioned that current knowledge and recent progress in AMPs action mechanisms, especially non-lytic features, mechanism of AMPs resistance and the potential problems associated with AMPs applications.

Key words： Antimicrobial peptides Non-membrane-disruptive mechanism Antibacterial mechanism Resistance

Received: 08 January 2019 Published: 18 September 2019

ZTFLH:

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Corresponding Authors: Ping GOU E-mail: gou__ping@sina.com

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Cite this article:

TANG Xin,MAO Xin-fang,MA Bin-yun,GOU Ping. Antimicrobial Peptides: Current Status and Future Challenges. China Biotechnology, 2019, 39(8): 86-94.

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https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20190812 OR https://manu60.magtech.com.cn/biotech/Y2019/V39/I8/86

Fig.1 Schematic representation of the major pathways targeted by AMPs


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