| Orginal Article |
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| Progress in Non-structural Protein 1 (NS1) Based Diagnosis of Flaviviruses Infection |
Zhou TONG( ),Jing-hua YAN |
| The Institute of Microbiology of the Chinese Academy of Sciences,Beijing 100101,China |
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Abstract Mosquito-borne flaviviruses provide some of the most important examples of emerging and resurging diseases of global significance. The early diagnosis of flaviviruses infection is important for successful clinical management and epidemiological control. Multiple RT-PCR-based assays for the detection of flaviviruses are limited to the narrow window when viral RNA is detectable in body fluids. Therefore, host immune reponse-based assays play an important role. Unfortunately, flaviviruses diagnosis are challenging due to the cross-reactive nature of antibodies among flaviviruses. The non-structural protein 1 (NS1) of flavivirus, a highly conserved and secreted glycoprotein, is abundant in the serum of flavivirus-infected patients and represents a useful early diagnostic marker. After ZIKV emerged as a global health threat, causing a pandemic in the Americas at 2016, lots of research groups focus on the NS1 based diagnosis. The improvements either from strategy or technology, which would significantly improve the differential diagnosis among flaviviruses infections.
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Received: 10 January 2019
Published: 26 March 2019
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