| Orginal Article |
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| The Research Advance of Long Non-coding RNA TERRA |
Yuan FAN1,Jia LUO1,Mai-lin GAN1,Ya TAN1,2,Shun-hua ZHANG1,**( ),Li ZHU1,**() |
1 College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China
2 Institute of Animal Husbandry and Veterinary, Guizhou Academy of Agricultural Science, Guiyang 550005, China |
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Abstract Telomeres are specialized structures at the ends of the chromosomes, which have protective effects on the ends of chromosomes, and are associated with aging and many diseases. Long non-coding RNAs are RNAs that are greater than 200bp in length and generally do not produce a protein product. TERRA (telomeric repeat-containing RNA) is a type of long non-coding RNA that transcribed from telomere repeats. Emerging studies have shown that TERRA has functions of regulating telomere length, promoting the formation of heterochromosomes, also protecting the ends of chromosomes, and the expression levels of TERRA are related to diseases and aging. Since TERRA plays an important role in telomeres, the studies of TERRA has become a spotlight in researches related to telomere. At present, the transcriptional regulation and biological functions of TERRA have been well studied. Reviewing the biological characteristics and functions of TERRA and its relationship with disease and aging provides reference for the subsequent study of TERRA, which may be act as a target for the treatment of disease treatment and aging.
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Received: 22 May 2018
Published: 09 November 2018
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Corresponding Authors:
Shun-hua ZHANG,Li ZHU
E-mail: 363445986@qq.com;zhuli7508@163.com
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