Research on the Regulatory Mechanisms of Bacterial Cell Wall Growth

doi:10.13523/j.cb.20180812

China Biotechnology

2018, Vol. 38

Issue (8): 92-99 DOI: 10.13523/j.cb.20180812

Research on the Regulatory Mechanisms of Bacterial Cell Wall Growth

Yue ZHAO¹,Hao WU¹,Jian-jun QIAO^1,^2,**(

)

^1. School of Chemical Engineering and Technology, Key Laboratory of Systems Bioengineering of Ministry of Education, Tianjin University, Tianjin 300072, China
^2. Syn Bio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin University, Tianjin 300072, China

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Abstract

Cell wall can maintain the shape and integrity of cell and resist internal expansion pressure during bacterial growth.The synthesis, division, regeneration, and recycling of cell wall are closely related to bacterial growth and the response to environmental stress. At present, the mechanism of cell wall growth, how to regulate cell wall growth and how to coordinate with other cellular processes remain largely unknown.The regulation mechanism of cell wall is very important for understanding the function of bacterial cell wall, determining the action of new drugs and developing the new generation of treatment methods. In this review, the bacterial regulatory mechanism of cell wall growth is summerized and the mechanisms of the scaffolding proteins, transcriptional regulators as well as small non-coding RNA and the protein-protein interaction to control the synthesis of cell wall, cell division and stress response are highlighted. In addition, the application of cell wall regulatory mechanism in the development of antibacterial drugs is summed up, and the future research direction is proposed.

Key words： Cell wall Scaffolding proteins Regulator sRNA Protein-protein interaction

Received: 13 April 2018 Published: 11 September 2018

ZTFLH:

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Corresponding Authors: Jian-jun QIAO E-mail: jianjunq@tju.edu.cn

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Cite this article:

Yue ZHAO,Hao WU,Jian-jun QIAO. Research on the Regulatory Mechanisms of Bacterial Cell Wall Growth. China Biotechnology, 2018, 38(8): 92-99.

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https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20180812 OR https://manu60.magtech.com.cn/biotech/Y2018/V38/I8/92

Fig.1 The regulatory mechanisms of bacterial cell wall

Fig.2 Peptidoglycan complex composed of scaffold proteins.


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