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| The Role of FoxO1 in the Impaired Metabolic Flexibility and Decompensation Progress of Pancreatic Beta Cell |
Lin-jing FENG1,Yang YV1,Hong-wei DU1,2,**( ) |
1 School of Basic Medical Sciences, Jilin University, Changchun 130021, China
2 The First Hospital of Jilin University, Changchun 130021, China |
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Abstract It is well known that glucose and fatty acids are key metabolic substrates for pancreatic β-cells. Pancreatic β-cells secrete insulin by glucose stimulating to keep blood glucose levels within a homeostatic range. When insulin resistance occurs, β-cells metabolic flexibility has become the first victim of pancreatic β-cells dysfunction. Compensation to decompensation of pancreatic β-cells is the key for the development of obesity insulin resistance to type 2 diabetes. Nuclear transcription factor FoxO1 (forkhead box O1) belongs to the Fox family, which is widely expressed in pancreatic β-cells. FoxO1 is a key regulator of the insulin-signaling pathway, and is reported to play important roles in pancreatic β-cells differentiation, proliferation, apoptosis and stress resistance. In view of the key role of FoxO1 in the maintenance of pancreatic β-cells function, an overview focused on the role of FoxO1 in the impaired metabolic flexibility and decompensation progress of pancreatic beta cells is provided.
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Received: 03 January 2018
Published: 06 July 2018
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Corresponding Authors:
Hong-wei DU
E-mail: dhw_101@126.com
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